Integrin beta 2 antibody

Catalog No. ABIN6939823

The Mouse Monoclonal anti-Integrin beta 2 antibody is suitable to detect Integrin beta 2 in samples from Human. It has been validated for FACS, IF and Func.

Quick Overview for Integrin beta 2 antibody (ABIN6939823)

Target: Integrin beta 2 (ITGB2)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Integrin beta 2 antibody is un-conjugated

Application: Flow Cytometry (FACS), Immunofluorescence (IF), Functional Studies (Func)

Clone: 68-5A5

Product Details anti-Integrin beta 2 Antibody

Purpose: CD18 / Integrin beta-2 (ITGB2) Antibody

Specificity: Integrins are heterodimers composed of noncovalently associated transmembrane both receptor clustering and ligand occupancy are necessary for the activation of integrinmediated responses. In addition to mediating cell adhesion and cytoskeletal organization, integrins function as signaling receptors. Signals transduced by integrins play a role in many biological processes, including cell growth, differentiation, migration and apoptosis.

Purification: 200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Stimulated human leukocytes

Isotype: IgG2a, kappa

Application Details

Application Notes:

Positive Control: Lymphocytes, granulocytes and macrophages in tonsil or lymph node.

Known Application: Functional Studies (Order Ab without Azide),Flow Cytometry (1-2 μg/million cells), Immunofluorescence (1-2 μg/mL), Optimal dilution for a specific application should be determined.

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Expiry Date: 24 months

Target Details for Integrin beta 2

Target: Integrin beta 2 (ITGB2)

Alternative Name: ITGB2

Background:

Beta 2 (antigen CD18 (p95), CD18, Cell surface adhesion glycoproteins LFA 1/CR3/p150,95 subunit beta, Cell surface adhesion glycoproteins LFA-1/CR3/p150, Complement component 3 receptor 3 and 4 subunit, Complement receptor C3 beta subunit, Integrin beta-2 (ITGB2), LAD, LCAMB, Leukocyte Cell Adhesion Molecule CD18, Lymphocyte function associated antigen 1 (LFA1), MAC1, Macrophage antigen 1 (mac1) beta

granulocytes and macrophages in tonsil or lymph node., Lymphocytes

Molecular Weight: 95kDa

Gene ID: 3689, 375957

UniProt: P05107

Pathways: NF-kappaB Signaling, Activation of Innate immune Response, Toll-Like Receptors Cascades, Activated T Cell Proliferation