RNLS antibody (AA 34-235)

Catalog No. ABIN6935974

Product Details anti-RNLS Antibody

Target: RNLS (Renalase, FAD-Dependent Amine Oxidase (RNLS))

Binding Specificity: AA 34-235

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This RNLS antibody is un-conjugated

Application: ELISA, Coating (Coat)

Purification: Purified by Protein A/G

Immunogen: Recombinant human RNLS protein fragment (around aa 34-235) (exact sequence is proprietary)

Clone: RNLS-1940

Isotype: IgG2b kappa

Application Details

Application Notes:

Positive Control: 293T cells. Heart or Kidney.

Known Application: ELISA (For coating, order antibody without BSA), Optimal dilution for a specific application should be determined.

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-80 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Expiry Date: 24 months

Target Details for RNLS

Target: RNLS (Renalase, FAD-Dependent Amine Oxidase (RNLS))

Alternative Name: RNLS (RNLS Products)

Synonyms: zgc:92286 antibody, C10orf59 antibody, RENALASE antibody, 6530404N21Rik antibody, AI452315 antibody, AW060440 antibody, RGD1309804 antibody, renalase, FAD dependent amine oxidase antibody, renalase, FAD-dependent amine oxidase antibody, RNLS antibody, rnls antibody, Rnls antibody

Background: Renalase is a 342 amino acid FAD-dependent amine oxidase that is highly expressed in kidney and is expressed at a lower level in heart, skeletal muscle and small intestine. Renalase is secreted in the blood by the kidney and it is thought to regulate cardiac function and systemic blood pressure. It is also suggested that Renalase functions as a hormone that metabolizes circulating catecholamines, which have an active role in the sympathetic and parasympathetic nervous systems. Individuals with chronic kidney disease and end-stage renal disease have markedly reduced levels of plasma Renalase than healthy individuals. Infusion of Renalase in animal models causes decrease in heart rate, cardiac contractility and blood pressure. Two isoforms of Renalase exist due to alternative splicing events.

Molecular Weight: 38kDa

Gene ID: 55328

UniProt: Q5VYX0