BCMA antibody (AA 78-184)

Catalog No. ABIN6940533

The Mouse Monoclonal anti-BCMA antibody is suitable to detect BCMA in samples from Human. It has been validated for ELISA and IHC.

Quick Overview for BCMA antibody (AA 78-184) (ABIN6940533)

Target: BCMA (TNFRSF17) (Tumor Necrosis Factor Receptor Superfamily, Member 17 (TNFRSF17))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This BCMA antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Clone: BCMA-2366

Product Details anti-BCMA Antibody

Binding Specificity: AA 78-184

Purpose: CD269 / TNFRSF17 / BCMA (B-Cell Maturation Protein) Antibody

Specificity: The B cell maturation protein (BCMA) is a type I integral membrane protein that belongs to the tumor necrosis factor receptor (TNF-R) superfamily. It is expressed as a 184 amino acid peptide that is expressed only in mature B-lymphocytes and is located on the cis part of the Golgi apparatus. BCMA shares significant homology with TACI (transmembrane activator) within the cysteine-rich domain. TACI has been shown to bind CAML, which induces activation of NFAT (nuclear factor of activated T cells). Both BCMA and TACI have been shown to bind APRIL and TALL-1, which stimulate B cell proliferation in conjunction with other B-cell activators. When overexpressed, TALL-1 stimulates the development of systemic lupus erythaematosus (SLE).

Purification: 200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant human CD269 protein fragment (around aa 78-184) (exact sequence is proprietary)

Isotype: IgG2c, kappa

Application Details

Application Notes:

Positive Control: NAMALWA cells. Tonsil or gastric carcinoma (IHC).

Known Application: ELISA (For coating, order antibody without BSA),Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT),(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Expiry Date: 24 months

Target Details for BCMA

Target: BCMA (TNFRSF17) (Tumor Necrosis Factor Receptor Superfamily, Member 17 (TNFRSF17))

Alternative Name: CD269

Background:

B-cell maturation protein, BCMA, CD269, TNR17, Tumor necrosis factor receptor superfamily member 17 (TNFRSF17)

NAMALWA cells. Tonsil or gastric carcinoma (IHC).

Molecular Weight: 20kDa

Gene ID: 608, 2556

UniProt: Q02223