CAMK4 antibody
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- Target See all CAMK4 Antibodies
- CAMK4 (Calcium/calmodulin-Dependent Protein Kinase IV (CAMK4))
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Reactivity
- Human, Mouse, Rat
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Host
- Rabbit
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Clonality
- Monoclonal
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Conjugate
- This CAMK4 antibody is un-conjugated
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Application
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Flow Cytometry (FACS)
- Cross-Reactivity
- Human, Mouse, Rat
- Purification
- Purified by Protein A.
- Immunogen
- Recombinant protein corresponding to the C-terminus of human CAMKIV.
- Clone
- 3F11
- Isotype
- IgG
- Top Product
- Discover our top product CAMK4 Primary Antibody
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- Application Notes
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WB 1:300-5000
FCM 1:20-100
IHC-P 1:200-400
IF(IHC-P) 1:50-200
IF(ICC) 1:50-200 - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.
- Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Storage
- 4 °C,-20 °C
- Storage Comment
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
- Expiry Date
- 12 months
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- Target
- CAMK4 (Calcium/calmodulin-Dependent Protein Kinase IV (CAMK4))
- Alternative Name
- CAMK4 (CAMK4 Products)
- Synonyms
- CaMK IV antibody, CaMK-GR antibody, IV antibody, caMK antibody, CAMK4 antibody, A430110E23Rik antibody, AI666733 antibody, CaMKIV antibody, CaMKIV/Gr antibody, D18Bwg0362e antibody, Ccdpk antibody, RATCCDPK antibody, camk4-A antibody, wu:fj42a03 antibody, zgc:110275 antibody, calcium/calmodulin dependent protein kinase IV antibody, calcium/calmodulin-dependent protein kinase IV antibody, calcium/calmodulin-dependent protein kinase IV L homeolog antibody, CAMK4 antibody, Camk4 antibody, camk4.L antibody, camk4 antibody
- Background
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Synonyms: Calcium/calmodulin-dependent protein kinase type IV, CaM kinase-GR, CaMK IV, CAMK4, CAMK, CAMK-GR, CAMKIV
Background: Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK4 signaling cascade and regulates, mainly by phosphorylation, the activity of several transcription activators, such as CREB1, MEF2D, JUN and RORA, which play pivotal roles in immune response, inflammation, and memory consolidation. In the thymus, regulates the CD4+/CD8+ double positive thymocytes selection threshold during T-cell ontogeny. In CD4 memory T-cells, is required to link T-cell antigen receptor (TCR) signaling to the production of IL2, IFNG and IL4 (through the regulation of CREB and MEF2). Regulates the differentiation and survival phases of osteoclasts and dendritic cells (DCs). Mediates DCs survival by linking TLR4 and the regulation of temporal expression of BCL2. Phosphorylates the transcription activator CREB1 on 'Ser-133' in hippocampal neuron nuclei and contribute to memory consolidation and long term potentiation (LTP) in the hippocampus. Can activate the MAP kinases MAPK1/ERK2, MAPK8/JNK1 and MAPK14/p38 and stimulate transcription through the phosphorylation of ELK1 and ATF2. Can also phosphorylate in vitro CREBBP, PRM2, MEF2A and STMN1/OP18.
- Gene ID
- 814
- UniProt
- Q16566
- Pathways
- EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Production of Molecular Mediator of Immune Response, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma
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