CDK7 antibody (pThr170) (Biotin)

Catalog No. ABIN6942496

The Rabbit Polyclonal anti-CDK7 antibody has been validated for WB, ELISA, IHC (p) and IHC (fro). It is suitable to detect CDK7 in samples from Human.

Quick Overview for CDK7 antibody (pThr170) (Biotin) (ABIN6942496)

Target: CDK7 (Cyclin-Dependent Kinase 7 (CDK7))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CDK7 antibody is conjugated to Biotin

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-CDK7 Antibody (Biotin)

Binding Specificity: pThr170

Cross-Reactivity: Human

Predicted Reactivity: Mouse,Rat,Dog,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated Synthesised phosphopeptide derived from human CDK7 around the phosphorylation site of Thr170

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for CDK7

Target: CDK7 (Cyclin-Dependent Kinase 7 (CDK7))

Alternative Name: CDK7

Background:

Synonyms: CDK7 (phospho Thr170), CDK7 (phospho T170), Cyclin H, MAT1, Cyclin Dependent Kinase 7, CAK1, MO15, CDKN7, serine/threonine kinase, STK1, serine/threonine protein kinase 1, MO15 homolog,Xenopus laevis, cdk-activating kinase, Cdk-activating kinase, serine/threonine protein kinase MO15, homolog of Xenopus MO15 Cdk-activating kinase, kinase subunit of CAK, 39 KDa protein kinase, CR4 protein kinase, CRK4, CDK7_HUMAN.

Background: The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This protein forms a trimeric complex with cyclin H and MAT1, which functions as a Cdk-activating kinase (CAK). It is an essential component of the transcription factor TFIIH, that is involved in transcription initiation and DNA repair. This protein is thought to serve as a direct link between the regulation of transcription and the cell cycle.

Gene ID: 1022

UniProt: P50613

Pathways: Cell Division Cycle, DNA Damage Repair, Intracellular Steroid Hormone Receptor Signaling Pathway, Mitotic G1-G1/S Phases, M Phase