MARK3 antibody (AA 600-750)

Catalog No. ABIN6944028

This Rabbit Monoclonal antibody specifically detects MARK3 in WB and FACS. It exhibits reactivity toward Human.

Quick Overview for MARK3 antibody (AA 600-750) (ABIN6944028)

Target: MARK3 (MAP/microtubule Affinity-Regulating Kinase 3 (MARK3))

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This MARK3 antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS)

Clone: 2F7

Product Details anti-MARK3 Antibody

Binding Specificity: AA 600-750

Purpose: MARK3 Recombinant Antibody

Cross-Reactivity: Human

Predicted Reactivity: Mouse

Purification: Purified by Protein A.

Immunogen: Recombinant protein within human Mark3 aa 600-750.

Isotype: IgG

Application Details

Application Notes: WB(1:500-2000), FCM(1:50-100)

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for MARK3

Target: MARK3 (MAP/microtubule Affinity-Regulating Kinase 3 (MARK3))

Alternative Name: MARK3

Background:

Synonyms: MAP/microtubule affinity-regulating kinase 3, C-TAK1, cTAK1, Cdc25C-associated protein kinase 1, ELKL motif kinase 2, EMK-2, Protein kinase STK10, Ser/Thr protein kinase PAR-1, Par-1a, Serine/threonine-protein kinase p78, microtubule affinity regulating kinase 3

Background: Serine/threonine-protein kinase. Involved in the specific phosphorylation of microtubule-associated proteins for MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU. Phosphorylates CDC25C on 'Ser-216'. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Negatively regulates the Hippo signaling pathway and antagonizes the phosphorylation of LATS1. Cooperates with DLG5 to inhibit the kinase activity of STK3/MST2 toward LATS1.

Gene ID: 4140

UniProt: P27448

Pathways: SARS-CoV-2 Protein Interactome