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NCOA1 antibody

This Rabbit Monoclonal antibody specifically detects NCOA1 in WB and IHC (p). It exhibits reactivity toward Human.
Catalog No. ABIN6944226

Quick Overview for NCOA1 antibody (ABIN6944226)

Target

See all NCOA1 Antibodies
NCOA1 (Nuclear Receptor Coactivator 1 (NCOA1))

Reactivity

  • 62
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  • 18
  • 3
  • 2
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  • 1
  • 1
  • 1
Human

Host

  • 68
  • 9
Rabbit

Clonality

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  • 19
Monoclonal

Conjugate

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  • 5
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  • 2
  • 2
  • 2
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  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
This NCOA1 antibody is un-conjugated

Application

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Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone

2G9
  • Cross-Reactivity

    Human

    Purification

    Purified by Protein A.

    Immunogen

    Recombinant protein within human KAT13A/ SRC1 aa 450-700

    Isotype

    IgG
  • Application Notes

    WB 1:300-5000
    IHC-P 1:200-400

    Restrictions

    For Research Use only
  • Format

    Liquid

    Concentration

    1 μg/μL

    Buffer

    Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.

    Preservative

    ProClin

    Precaution of Use

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    Storage

    4 °C,-20 °C

    Storage Comment

    Store at 4°C for up to 2 weeks. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

    Expiry Date

    12 months
  • Target

    NCOA1 (Nuclear Receptor Coactivator 1 (NCOA1))

    Alternative Name

    NCOA1

    Background

    Synonyms: Nuclear receptor coactivator 1, Class E basic helix-loop-helix protein 74, Protein Hin-2, RIP160, Renal carcinoma antigen NY-REN-52, Steroid receptor coactivator 1, NCoA-1, bHLHe74, SRC-1, NCOA1, BHLHE74, SRC1

    Background: Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). Also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. Displays histone acetyltransferase activity toward H3 and H4, the relevance of such activity remains however unclear. Plays a central role in creating multisubunit coactivator complexes that act via remodeling of chromatin, and possibly acts by participating in both chromatin remodeling and recruitment of general transcription factors. Required with NCOA2 to control energy balance between white and brown adipose tissues. Required for mediating steroid hormone response. Isoform 2 has a higher thyroid hormone-dependent transactivation activity than isoform 1 and isoform 3.

    Gene ID

    8648

    UniProt

    Q15788

    Pathways

    Intracellular Steroid Hormone Receptor Signaling Pathway, Nuclear Hormone Receptor Binding, Chromatin Binding, Regulation of Lipid Metabolism by PPARalpha
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