NCOA1 antibody
Quick Overview for NCOA1 antibody (ABIN6944226)
Target
See all NCOA1 AntibodiesReactivity
Host
Clonality
Conjugate
Application
Clone
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Cross-Reactivity
- Human
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Purification
- Purified by Protein A.
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Immunogen
- Recombinant protein within human KAT13A/ SRC1 aa 450-700
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Isotype
- IgG
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Application Notes
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WB 1:300-5000
IHC-P 1:200-400 -
Restrictions
- For Research Use only
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Format
- Liquid
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Concentration
- 1 μg/μL
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Buffer
- Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.
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Preservative
- ProClin
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Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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Storage
- 4 °C,-20 °C
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Storage Comment
- Store at 4°C for up to 2 weeks. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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Expiry Date
- 12 months
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- NCOA1 (Nuclear Receptor Coactivator 1 (NCOA1))
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Alternative Name
- NCOA1
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Background
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Synonyms: Nuclear receptor coactivator 1, Class E basic helix-loop-helix protein 74, Protein Hin-2, RIP160, Renal carcinoma antigen NY-REN-52, Steroid receptor coactivator 1, NCoA-1, bHLHe74, SRC-1, NCOA1, BHLHE74, SRC1
Background: Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). Also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. Displays histone acetyltransferase activity toward H3 and H4, the relevance of such activity remains however unclear. Plays a central role in creating multisubunit coactivator complexes that act via remodeling of chromatin, and possibly acts by participating in both chromatin remodeling and recruitment of general transcription factors. Required with NCOA2 to control energy balance between white and brown adipose tissues. Required for mediating steroid hormone response. Isoform 2 has a higher thyroid hormone-dependent transactivation activity than isoform 1 and isoform 3.
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Gene ID
- 8648
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UniProt
- Q15788
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Pathways
- Intracellular Steroid Hormone Receptor Signaling Pathway, Nuclear Hormone Receptor Binding, Chromatin Binding, Regulation of Lipid Metabolism by PPARalpha
Target
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