Notch1 antibody (Notch 1)

Details for Product anti-NOTCH1 Antibody No. ABIN6944302
Antigen
  • notch1
  • NOTCH1
  • hn1
  • tan1
  • notch
  • xotch
  • xnotch
  • notch-1
  • xnotch1
  • TAN1
  • hN1
  • 9930111A19Rik
  • Mis6
  • N1
  • Tan1
  • lin-12
  • NOTCH
  • Xotch
  • notch1-a
  • notch 1
  • fibropellin-1
  • Notch homolog 1, translocation-associated (Drosophila)
  • Notch homolog 1, translocation-associated
  • notch 1 S homeolog
  • notch1
  • LOC100631526
  • NOTCH1
  • Notch1
  • notch1.S
Reactivity
Human, Mouse (Murine)
232
151
79
20
4
4
2
2
2
1
1
1
1
1
1
Host
Rabbit
180
98
12
7
6
3
1
Clonality (Clone)
Monoclonal ()
Conjugate
This Notch1 antibody is un-conjugated
16
15
11
10
7
4
4
3
3
3
3
3
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunohistochemistry (IHC), Western Blotting (WB)
182
99
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64
47
45
24
23
13
11
8
5
3
3
2
2
2
2
1
Options
Immunogen Recombinant human Notch1 between 2500 to 2600 amino acids
Clone 1F1
Isotype IgG
Purification Purified by Protein A.
Plasmids, Primers & others Plasmids, Primers & others Notch1 products on genomics-online (e.g. as negative or positive controls)
Antigen
Alternative Name Notch 1 (NOTCH1 Antibody Abstract)
Background

Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis, negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the maturation of both CD4+ and CD8+ cells in the thymus. Important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia. Represses neuronal and myogenic differentiation. May play an essential role in postimplantation development, probably in some aspect of cell specification and/or differentiation. May be involved in mesoderm development, somite formation and neurogenesis. May enhance HIF1A function by sequestering HIF1AN away from HIF1A. Required for the THBS4 function in regulating protective astrogenesis from the subventricular zone (SVZ) niche after injury. Involved in determination of left/right symmetry by modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO).


Synonyms: Neurogenic locus notch homolog protein 1, Translocation-associated notch protein TAN-1, Notch 1, hN1
Gene ID 4851
UniProt P46531
Pathways Notch Signaling, Stem Cell Maintenance, Regulation of Muscle Cell Differentiation, Tube Formation, Skeletal Muscle Fiber Development
Application Notes WB(1:300-1000), FCM(1:20-100), IF(ICC)(1:50-200), IHC()
Restrictions For Research Use only
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Expiry Date 12 months
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