Cadherin antibody

Catalog No. ABIN6944414

This anti-Cadherin antibody is a Rabbit Monoclonal antibody detecting Cadherin in WB, FACS, IF (cc), IHC and IHC (p). Suitable for Human, Mouse and Rat.

Quick Overview for Cadherin antibody (ABIN6944414)

Target: Cadherin

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Monoclonal

Conjugate: This Cadherin antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: 9A1

Product Details anti-Cadherin Antibody

Cross-Reactivity: Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: C-terminus human Cadherin

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
FCM 1:20-100
IHC-P 1:200-400
IF(ICC) 1:50-200
IHC()

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for Cadherin

Target: Cadherin

Background:

Synonyms: Cadherin-1, CAM 120/80, Epithelial cadherin, Uvomorulin, CD_antigen: CD324, Cadherin-2, CDw325, Neural cadherin, CD_antigen: CD325, Cadherin-3, Placental cadherin, 7B4 antigen, Vascular endothelial cadherin, CD_antigen: CD144, Cadherin-4, Retinal cadherin, E-cadherin, CDH1, CDHE, UVO, CDH2, CDHN, NCAD, P-cadherin, CDH3, CDHP, VE-cadherin, CDH5, R-CAD, R-cadherin

Background: Cadherins comprise a family of Ca2+-dependent adhesion molecules that function to mediate cell-cell binding critical to the maintenance of tissue structure and morphogenesis. The classical cadherins, E-, N- and P-cadherin, consist of large extracellular domains characterized by a series of five homologous NH2 terminal repeats. The most distal of these cadherins is thought to be responsible for binding specificity, transmembrane domains and carboxy terminal intracellular domains. The relatively short intracellular domains interact with a variety of cytoplasmic proteins, such as -catenin, to regulate cadherin function. Members of this family of adhesion proteins include rat cadherin K (and its human homolog, cadherin, R-cadherin, B-cadherin, E/P cadherin and cadherin-5.

UniProt: P12830, P19022, P22223