Recombinant PAX6 antibody (AA 250-350)

Catalog No. ABIN6944444

The Rabbit Monoclonal anti-PAX6 antibody (ABIN6944444) specifically detects PAX6 in WB, IHC (p), IF (p) and IHC (fro). The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for Recombinant PAX6 antibody (AA 250-350) (ABIN6944444)

Target: PAX6 (Paired Box 6 (PAX6))

Antibody Type: Recombinant Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Monoclonal

Conjugate: This PAX6 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-PAX6 Antibody

Binding Specificity: AA 250-350

Purpose: PAX6 Recombinant Antibody

Cross-Reactivity: Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: Human PAX6 between 250 to 350 amino acids

Isotype: IgG

Application Details

Application Notes: WB(WB(1:500-3000)), IHC-P(IHC-P(1:100-500)), IHC-F(IHC-F(1:100-500)), IF(IHC-P)(IF(IHC-P)(1:100-500))

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: 0.01M TBS ( pH 7.4), 1 % BSA, 0.02 % Proclin 300, and 50 % Glycerol

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for up to 2 weeks. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 12 months

Target Details for PAX6

Target: PAX6 (Paired Box 6 (PAX6))

Alternative Name: PAX6

Background:

Synonyms: Paired box protein Pax-6, Aniridia type II protein, Oculorhombin, PAX6

Background: Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells (By similarity). Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains (By similarity). Isoform 5a appears to function as a molecular switch that specifies target genes.

UniProt: P26367

Pathways: Peptide Hormone Metabolism, Carbohydrate Homeostasis