PD-1 antibody (Programmed Cell Death 1) (AA 80-130) (Biotin)

Details for Product anti-PDCD1 Antibody No. ABIN6944456
Antigen
  • CD279
  • PD-1
  • PD1
  • SLEB2
  • hPD-1
  • hPD-l
  • Ly101
  • Pdc1
  • programmed cell death 1
  • PDCD1
  • Pdcd1
Epitope
AA 80-130
18
15
15
12
10
8
8
8
6
6
5
4
3
3
3
3
2
2
1
1
1
1
Reactivity
Human
374
145
51
5
3
1
Host
Rabbit
196
174
36
24
17
12
5
4
2
Clonality
Polyclonal
Conjugate
This PD-1 antibody is conjugated to Biotin
29
20
20
12
8
7
5
5
4
4
4
4
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
Application
Western Blotting (WB)
245
175
129
110
93
71
26
15
15
13
12
11
10
10
9
5
4
4
2
2
Options
Immunogen KLH conjugated synthetic peptide derived from human PD-1
Isotype IgG
Purification Purified by Protein A.
Plasmids, Primers & others Plasmids, Primers & others PD-1 products on genomics-online (e.g. as negative or positive controls)
Antigen
Alternative Name PD-1 (PDCD1 Antibody Abstract)
Background

This gene encodes a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases.
CD279 is an immunoglobulin superfamily member, also known as Programmed Cell Death 1. Programmed Cell Death 1 is expressed on a subset of CD4-CD8 thymocytes, and on activated T and B cells. Programmed Cell Death 1 is thought to be involved in lymphocyte clonal selection and peripheral tolerance. The Programmed Cell Death 1 ligands, PDL1 (also known as B7H1) and PDL2 (B7DC), are members of the B7 immunoglobulin superfamily.

Subcellular location: Extracellular


Synonyms: CD279, CD279 antigen, hPD 1, hPD l, hPD-1, hSLE1, PD 1, PD1, PDCD 1, PDCD1, PDCD1_HUMAN, Programmed cell death 1, Programmed cell death protein 1, Protein PD 1, Protein PD-1, SLEB2, Systemic lupus erythematosus susceptibility 2.
Gene ID 5133
UniProt Q15116
Pathways Cancer Immune Checkpoints
Application Notes WB(1:500-2000)
Restrictions For Research Use only
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Expiry Date 12 months
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