PDIA6 antibody

Catalog No. ABIN6944473

Product Details anti-PDIA6 Antibody

Target: PDIA6 (Protein Disulfide Isomerase Family A, Member 6 (PDIA6))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Monoclonal

Conjugate: This PDIA6 antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc))

Cross-Reactivity: Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: Human PDIA6 between 300 to 500 amino acids

Clone: 4C3

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
FCM 1:20-100
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for PDIA6

Target: PDIA6 (Protein Disulfide Isomerase Family A, Member 6 (PDIA6))

Alternative Name: PDIA6 (PDIA6 Products)

Synonyms: 1700015E05Rik antibody, AL023058 antibody, C77895 antibody, CaBP5 antibody, P5 antibody, Txndc7 antibody, ERP5 antibody, TXNDC7 antibody, CaBP1 antibody, pdi-p5 antibody, erp5 antibody, pdia6 antibody, pdip5 antibody, txndc7 antibody, protein disulfide isomerase family A member 6 antibody, protein disulfide isomerase associated 6 antibody, protein disulfide isomerase family A, member 6 antibody, protein disulfide isomerase family A member 6 L homeolog antibody, PDIA6 antibody, Pdia6 antibody, pdia6.L antibody

Background:

Synonyms: Protein disulfide-isomerase A6, Endoplasmic reticulum protein 5, Protein disulfide isomerase P5, Thioredoxin domain-containing protein 7, ER protein 5, ERp5, PDIA6

Background: May function as a chaperone that inhibits aggregation of misfolded proteins (PubMed:12204115). Negatively regulates the unfolded protein response (UPR) through binding to UPR sensors such as ERN1, which in turn inactivates ERN1 signaling (PubMed:24508390). May also regulate the UPR via the EIF2AK3 UPR sensor (PubMed:24508390). Plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin (PubMed:15466936).

Gene ID: 10130

UniProt: Q15084

Pathways: ER-Nucleus Signaling, Cell RedoxHomeostasis