PDX1 antibody (Pancreatic and Duodenal Homeobox 1)

Details for Product anti-PDX1 Antibody No. ABIN6944477
Antigen
  • GSF
  • IDX-1
  • IPF1
  • IUF1
  • MODY4
  • PDX-1
  • STF-1
  • ipf1
  • PDX1
  • IPF-1
  • Ipf1
  • Mody4
  • pdx-1
  • Idx1
  • Stf1
  • zgc:100874
  • XlHbox-8
  • xlhbox8
  • pancreatic and duodenal homeobox 1
  • pancreatic and duodenal homeobox 1 S homeolog
  • PDX1
  • pdx1
  • Pdx1
  • pdx1.S
Reactivity
Human
241
85
70
7
7
6
5
4
4
3
2
2
2
2
1
1
1
Host
Rabbit
221
29
5
Clonality (Clone)
Monoclonal ()
Conjugate
This PDX1 antibody is un-conjugated
17
11
11
10
10
10
7
7
7
7
7
7
1
1
1
1
1
Application
Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
151
120
70
33
24
15
11
10
6
5
3
3
2
2
1
Options
Immunogen Synthetic peptide within C-terminal human PDX1
Clone 34A1
Isotype IgG
Purification Purified by Protein A.
Plasmids, Primers & others Plasmids, Primers & others PDX1 products on genomics-online (e.g. as negative or positive controls)
Antigen
Alternative Name PDX1
Background

Activates insulin, somatostatin, glucokinase, islet amyloid polypeptide and glucose transporter type 2 gene transcription. Particularly involved in glucose-dependent regulation of insulin gene transcription. Binds preferentially the DNA motif 5'-[CT]TAAT[TG]-3'. During development, specifies the early pancreatic epithelium, permitting its proliferation, branching and subsequent differentiation. At adult stage, required for maintaining the hormone-producing phenotype of the beta-cell.


Synonyms: Pancreas/duodenum homeobox protein 1, Glucose-sensitive factor, Insulin promoter factor 1, Insulin upstream factor 1, Islet/duodenum homeobox-1, Somatostatin-transactivating factor 1, PDX-1, GSF, IPF-1, IUF-1, IDX-1, STF-1, IUF1, MODY4, PAGEN1.
Gene ID 3651
UniProt P52945
Pathways Nuclear Receptor Transcription Pathway, Positive Regulation of Peptide Hormone Secretion, Steroid Hormone Mediated Signaling Pathway, Hormone Transport, Carbohydrate Homeostasis, Chromatin Binding, Maintenance of Protein Location
Application Notes IHC-P(1:50-200), IF(IHC-P)(1:50-200), IF(ICC)(1:50-200)
Restrictions For Research Use only
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Expiry Date 12 months
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