Protein Kinase D1 (PRKD1) antibody

Details for Product No. ABIN6944657
Target
Reactivity
Human, Mouse, Rat
156
120
105
8
8
4
4
4
3
2
2
2
2
1
1
Host
Rabbit
155
2
2
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
9
7
6
6
6
6
6
4
4
2
2
2
2
2
2
2
2
Application
Western Blotting (WB)
112
55
50
27
22
19
5
5
5
3
1
Options
Immunogen Human PKC mu aa 500-650
Clone 10C1
Isotype IgG
Purification Purified by Protein A.
Target
Alternative Name PRKD1 (PRKD1 Antibody Abstract)
Background

Converts transient diacylglycerol (DAG) signals into prolonged physiological effects, downstream of PKC. In epithelial cells, is required for transducing flagellin-stimulated inflammatory responses by binding and phosphorylating TLR5, which contributes to MAPK14/p38 activation and production of inflammatory cytokines. May play a role in inflammatory response by mediating activation of NF-kappa-B. May be involved in pain transmission by directly modulating TRPV1 receptor. Plays a role in activated KRAS-mediated stabilization of ZNF304 in colorectal cancer (CRC) cells. Regulates nuclear translocation of transcription factor TFEB in macrophages upon live S.enterica infection.


Synonyms: Serine/threonine-protein kinase D1, Protein kinase C mu type, Protein kinase D, nPKC-D1, nPKC-mu, PRKD1, PKD, PKD1, PRKCM, PKC mu, CHDED.
Gene ID 5587
UniProt Q15139
Pathways Myometrial Relaxation and Contraction
Application Notes WB(1:500-2000)
Restrictions For Research Use only
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Expiry Date 12 months