GZMA antibody (Biotin)

Catalog No. ABIN6963891

There are 4+ publications for this product available. The Mouse Monoclonal anti-GZMA antibody is suitable to detect GZMA in samples from Human. It has been validated for ELISA.

Quick Overview for GZMA antibody (Biotin) (ABIN6963891)

Target: GZMA (Granzyme A (Granzyme 1, Cytotoxic T-Lymphocyte-Associated serine Esterase 3) (GZMA))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This GZMA antibody is conjugated to Biotin

Application: ELISA

Clone: GA28

Product Details anti-GZMA Antibody (Biotin)

Specificity: Native and recombinant Granzyme A

Purification: Biotinylated through reaction with a N-hydroxysuccinimide ester of biotin.,Purified from in vitro cultures by protein G affinity chromatography.

Sterility: 0.2 μm filtered

Immunogen: Human granzyme A

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: supplied at 0.5 mg/mL in PBS with 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store product at 4-8°C or frozen at -20°C or below. Avoid repeated freezing/ thawing.

Expiry Date: 18 months

References for anti-GZMA antibody (Biotin) (ABIN6963891)

Tang, Zha, Guo, Shi, Xu: "CXCR5+CD8+ T cells present elevated capacity in mediating cytotoxicity toward autologous tumor cells through interleukin 10 in diffuse large B-cell lymphoma." in: International immunopharmacology, Vol. 50, pp. 146-151, (2018) (PubMed).

Ma, Huang, Zhang, Wang, Chen: "Exposure to particulate matter 2.5 (PM2.5) induced macrophage-dependent inflammation, characterized by increased Th1/Th17 cytokine secretion and cytotoxicity." in: International immunopharmacology, Vol. 50, pp. 139-145, (2018) (PubMed).

Qiu, Hu, Gao, Chen, Chen, Yuan, Huang, Xu, Yang: "Interleukin 10 enhanced CD8+ T cell activity and reduced CD8+ T cell apoptosis in patients with diffuse large B cell lymphoma." in: Experimental cell research, Vol. 360, Issue 2, pp. 146-152, (2017) (PubMed).

Herth, Witzens-Harig, Beckhove, Hose, Meissner, Neuber, Engelhardt, Haas, Neben, Ho, Klein, Goldschmidt, Hundemer: "Thalidomide maintenance therapy maturates the T cell compartment and compromises antigen-specific antitumor immunity in patients with multiple myeloma." in: Experimental hematology, Vol. 41, Issue 3, pp. 231-40, (2013) (PubMed).

Target Details for GZMA

Target: GZMA (Granzyme A (Granzyme 1, Cytotoxic T-Lymphocyte-Associated serine Esterase 3) (GZMA))

Alternative Name: Granzyme A

Gene ID: 3001

Pathways: Apoptosis