LGI2 antibody (AA 201-300) (Alexa Fluor 350)

Catalog No. ABIN6976734

Product Details anti-LGI2 Antibody (Alexa Fluor 350)

Target: LGI2 (Leucine-Rich Repeat LGI Family, Member 2 (LGI2))

Binding Specificity: AA 201-300

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LGI2 antibody is conjugated to Alexa Fluor 350

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Cross-Reactivity: Mouse

Predicted Reactivity: Human,Rat,Cow,Sheep,Pig,Horse,Chicken,Guinea Pig

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human LGI2

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for LGI2

Target: LGI2 (Leucine-Rich Repeat LGI Family, Member 2 (LGI2))

Alternative Name: LGI2 (LGI2 Products)

Synonyms: LGIL2 antibody, mKIAA1916 antibody, leucine rich repeat LGI family member 2 antibody, leucine-rich repeat LGI family, member 2 antibody, leucine-rich repeat LGI family member 2 antibody, leucine-rich repeat LGI family, member 2a antibody, LGI2 antibody, Lgi2 antibody, lgi2 antibody, lgi2a antibody

Background:

Synonyms: KIAA1916, Leucine rich glioma inactivated protein 2, Leucine rich repeat LGI family member 2, Leucine-rich glioma-inactivated protein 2, Leucine-rich repeat LGI family member 2, LGI1 like protein 2, LGI1-like protein 2, LGI2, LGI2_HUMAN, LGIL2.

Background: The leucine-rich (LRR) repeat is a 20-30 amino acid motif that forms a hydrophobic Alpha/Beta horseshoe fold, allowing it to accommodate several leucine residues within a tightly packed core. All LRR repeats contain a variable segment and a highly conserved segment, the latter of which accounts for 11 or 12 residues of the entire LRR motif. LGI2 (leucine-rich repeat LGI family, member 2), also known as KIAA1916 or LGIL2, is a 545 amino acid secreted protein that contains four LRR repeats and seven EAR repeats. Expressed in heart, brain and placenta, LGI2 shares high sequence similarity with other LGI family members and is thought to play a role in the pathogenesis of epileptic disorders.

Gene ID: 55203

UniProt: Q8N0V4