KPNA6 antibody (AA 101-200) (Alexa Fluor 647)

Catalog No. ABIN6980005

Product Details anti-KPNA6 Antibody (Alexa Fluor 647)

Target: KPNA6 (Karyopherin alpha 6 (Importin alpha 7) (KPNA6))

Binding Specificity: AA 101-200

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KPNA6 antibody is conjugated to Alexa Fluor 647

Application: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Cross-Reactivity: Human, Mouse

Predicted Reactivity: Rat,Cow,Sheep,Pig,Horse,Chicken

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human KPNA6

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for KPNA6

Target: KPNA6 (Karyopherin alpha 6 (Importin alpha 7) (KPNA6))

Alternative Name: KPNA6 (KPNA6 Products)

Synonyms: IPOA7 antibody, Kpna5 antibody, NPI-2 antibody, KPNA7 antibody, karyopherin subunit alpha 6 antibody, karyopherin (importin) alpha 6 antibody, karyopherin alpha 6 (importin alpha 7) antibody, karyopherin alpha 6 (importin alpha 7) S homeolog antibody, KPNA6 antibody, Kpna6 antibody, kpna6.S antibody

Background:

Synonyms: Importin subunit alpha-7, KPNA6, Karyopherin subunit alpha-6, KPNA6, IPOA7

Background: Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.

Gene ID: 23633

UniProt: O60684

Pathways: Protein targeting to Nucleus