NFKB1 antibody (AA 871-968) (Cy7)

Catalog No. ABIN6986525

The Rabbit Polyclonal anti-NFKB1 antibody has been validated for IF (cc), IF (p) and FACS. It is suitable to detect NFKB1 in samples from Human.

Quick Overview for NFKB1 antibody (AA 871-968) (Cy7) (ABIN6986525)

Target: NFKB1 (Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells 1 (NFKB1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NFKB1 antibody is conjugated to Cy7

Application: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Flow Cytometry (FACS)

Product Details anti-NFKB1 Antibody (Cy7)

Binding Specificity: AA 871-968

Cross-Reactivity: Human

Predicted Reactivity: Pig

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human NFkB p105

Isotype: IgG

Application Details

Application Notes: FCM 1:20-100
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for NFKB1

Target: NFKB1 (Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells 1 (NFKB1))

Alternative Name: NFkB p105

Background:

Synonyms: NFkB p105, NFkB p105, DKFZp686C01211, DNA binding factor KBF1, DNA binding factor KBF1 EBP1, DNA binding factor KBF1 EBP1, DNA-binding factor KBF1, EBP 1, EBP-1, EBP1, KBF1, MGC54151, NF kappa B, NF kappabeta, NF kB1, NFKB 1, NFKB p105, NFKB1, NFKB1_HUMAN, Nuclear factor kappa B DNA binding subunit, Nuclear factor NF kappa B p105 subunit, Nuclear factor of kappa light polypeptide gene enhancer in B cells 1, Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p84/NF-kappa-B1 p98.

Background: This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009].

Gene ID: 4790

UniProt: P19838

Pathways: p53 Signaling, NF-kappaB Signaling, RTK Signaling, TCR Signaling, TLR Signaling, Fc-epsilon Receptor Signaling Pathway, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Myometrial Relaxation and Contraction, Regulation of Carbohydrate Metabolic Process, Hepatitis C, Toll-Like Receptors Cascades, BCR Signaling, S100 Proteins