CBX3 antibody

Catalog No. ABIN6989459

The Mouse Monoclonal anti-CBX3 antibody is suitable to detect CBX3 in samples from Human. It has been validated for WB, IHC (p), IF (cc), IF (p) and IHC (fro).

Quick Overview for CBX3 antibody (ABIN6989459)

Target: CBX3 (Chromobox Homolog 3 (CBX3))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CBX3 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Clone: 5B9

Product Details anti-CBX3 Antibody

Purpose: HP1 gamma Monoclonal Antibody

Cross-Reactivity: Human, Mouse, Rat

Purification: Purified by Protein G.

Immunogen: Recombinant human HP1 gamma Protein

Isotype: IgG

Application Details

Application Notes: WB(1:300-5000),

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for CBX3

Target: CBX3 (Chromobox Homolog 3 (CBX3))

Alternative Name: HP1 gamma

Background:

Synonyms: CBX 3, CBX3, Chromobox homolog 3, Chromobox protein homolog 3, HECH, Heterochromatin like protein 1, Heterochromatin protein 1 homolog gamma, Heterochromatin protein HP1 gamma, HP1 gamma homolog, HP1Hs gamma , Modifier 2, protein HP1-GAMMA, HP1g, M32, MGC118084, CBX3_HUMAN, Modifier 2 protein,

Background: Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins.

Gene ID: 11335

UniProt: Q13185