SOCS6 antibody (AA 21-120)

Catalog No. ABIN6989474

The Rabbit Polyclonal anti-SOCS6 antibody has been validated for WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) and ICC. It is suitable to detect SOCS6 in samples from Mouse and Chicken.

Quick Overview for SOCS6 antibody (AA 21-120) (ABIN6989474)

Target: SOCS6 (Suppressor of Cytokine Signaling 6 (SOCS6))

Reactivity: Mouse, Chicken

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SOCS6 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC)

Product Details anti-SOCS6 Antibody

Binding Specificity: AA 21-120

Cross-Reactivity: Chicken, Mouse

Predicted Reactivity: Human,Rat,Dog,Cow,Sheep,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human SOCS6

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for SOCS6

Target: SOCS6 (Suppressor of Cytokine Signaling 6 (SOCS6))

Alternative Name: SOCS6

Background:

Synonyms: CIS-4, CIS4, Cish4, Cytokine inducible SH2 protein 4, Cytokine-inducible SH2 protein 4, HSPC060, SOCS-4, SOCS-6, SOCS4, Socs6, SOCS6_HUMAN, SSI4, STAI4, STAT induced STAT inhibitor 4, STAT4, STATI4, Suppressor of cytokine signaling 4, Suppressor of cytokine signaling 6.

Background: The protein encoded by this gene contains a SH2 domain and a CIS homolog domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by GM-CSF and EPO in hematopoietic cells. A high expression level of this gene was found in factor-independent chronic myelogenous leukemia (CML) and erythroleukemia (HEL) cell lines. [provided by RefSeq, Jul 2008].

Gene ID: 9306

UniProt: O14544

Pathways: JAK-STAT Signaling, Carbohydrate Homeostasis