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ACE2 antibody (AA 150-200)

ACE2 Reactivity: Human, Mouse, Rat WB, ELISA, IHC (p), IF Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6990119
  • Target See all ACE2 Antibodies
    ACE2 (Angiotensin I Converting Enzyme 2 (ACE2))
    Binding Specificity
    • 16
    • 14
    • 12
    • 9
    • 9
    • 9
    • 6
    • 5
    • 5
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 150-200
    Reactivity
    • 142
    • 53
    • 46
    • 6
    • 5
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 129
    • 20
    • 6
    Rabbit
    Clonality
    • 108
    • 47
    Polyclonal
    Conjugate
    • 80
    • 16
    • 10
    • 8
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This ACE2 antibody is un-conjugated
    Application
    • 122
    • 67
    • 50
    • 36
    • 35
    • 19
    • 17
    • 11
    • 11
    • 10
    • 10
    • 6
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)
    Specificity
    Anti-ACE2 has no cross response to ACE1.
    Purification
    ACE2 Antibody is affinity chromatography purified via peptide column.
    Immunogen
    ACE2 antibody was raised against a synthetic peptide corresponding to amino acids near the center of human ACE2. The immunogen is located within amino acids 150 - 200 of ACE2.
    Isotype
    IgG
    Top Product
    Discover our top product ACE2 Primary Antibody
  • Application Notes
    WB: 4 μ,g/mL, IHC: 2 μ,g/mL, IF: 20 μ,g/mL.

    Antibody validated: Western Blot in human, mouse and rat samples, Immunohistochemistry in human, mouse and rat samples, Immunofluorescence in human, mouse, and rat samples. All other applications and species not yet tested.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    ACE2 Antibody is supplied in PBS containing 0.02 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C,4 °C
    Storage Comment
    ACE2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • Target
    ACE2 (Angiotensin I Converting Enzyme 2 (ACE2))
    Alternative Name
    ACE2 (ACE2 Products)
    Synonyms
    ACE1 antibody, CD143 antibody, DCP antibody, DCP1 antibody, ICH antibody, MVCD3 antibody, ACEH antibody, 2010305L05Rik antibody, zgc:92514 antibody, angiotensin I converting enzyme antibody, angiotensin I converting enzyme 2 antibody, angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 antibody, ACE antibody, ACE2 antibody, Ace2 antibody, ace2 antibody
    Background

    ACE2 Antibody: Angiotensin-converting enzyme 2 (ACE2) plays a central role in vascular, renal, and myocardial physiology. In contrast to its homolog ACE, ACE2 expression is restricted to heart, kidney, and testis. Recently. ACE2 has also been shown to be a functional receptor of the SARS coronavirus. Homology modeling shows 2019-nCoV has a similar receptor-binding domain structure as SARS-CoV, which suggests COVID-19 (2019-nCoV) may use ACE2 as a receptor in humans for infection. The normal function of ACE2 is to convert the inactive vasoconstrictor angiotensin I (AngI) to Ang1-9 and the active form AngII to Ang1-7, unlike ACE, which converts AngI to AngII. While the role of these vasoactive peptides is not well understood, lack of ACE2 expression in ace2-/ace2- mice leads to severely reduced cardiac contractility, indicating its importance in regulating heart function.

    Molecular Weight
    Predicted: 93kD

    Observed: 130 kD (7 N-linked glycosylation) kDa
    Gene ID
    59272
    NCBI Accession
    NP_068576
    UniProt
    Q9BYF1
    Pathways
    ACE Inhibitor Pathway, Peptide Hormone Metabolism, Regulation of Systemic Arterial Blood Pressure by Hormones, Feeding Behaviour
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