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SARS-CoV-2 NSP14 antibody (AA 120-170)

ExoN Reactivity: SARS Coronavirus-2 (SARS-CoV-2) ELISA, IHC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6990150
  • Target See all SARS-CoV-2 NSP14 (ExoN) products
    SARS-CoV-2 NSP14 (ExoN) (SARS-CoV-2 Guanine-N7 Methyltransferase (NSP14) (ExoN))
    Binding Specificity
    • 1
    • 1
    AA 120-170
    Reactivity
    SARS Coronavirus-2 (SARS-CoV-2)
    Host
    • 1
    • 1
    Rabbit
    Clonality
    • 2
    Polyclonal
    Conjugate
    • 2
    This SARS-CoV-2 NSP14 antibody is un-conjugated
    Application
    ELISA, Immunohistochemistry (IHC)
    Purification
    SARS-CoV-2 (COVID-19) NSP14 (ExoN) Antibody is affinity chromatography purified via peptide column.
    Immunogen
    Anti-SARS-CoV-2 (COVID-19) NSP14 (ExoN) antibody was raised against a peptide corresponding to 14 amino acids near the center of SARS-CoV-2 (COVID-19) NSP14 (ExoN) protein. The immunogen is located between 120-170 amino acids of SARS-CoV-2 (COVID-19) NSP14 (ExoN).
    Isotype
    IgG
  • Application Notes
    IHC: 0.5 μ,g/mL .

    Antibody validated: Immunohistochemistry in human samples. SARS-CoV-2 (COVID-19) NSP14 (ExoN) antibody can detect 2 ng of free peptide at 1 μ,g/mL in ELISA. All other applications and species not yet tested
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    SARS-CoV-2 (COVID-19) NSP14 (ExoN) Antibody is supplied in PBS containing 0.02 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C,4 °C
    Storage Comment
    SARS-CoV-2 (COVID-19) NSP14 (ExoN) antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • Target
    SARS-CoV-2 NSP14 (ExoN) (SARS-CoV-2 Guanine-N7 Methyltransferase (NSP14) (ExoN))
    Alternative Name
    SARS-CoV-2 Guanine-N7 Methyltransferase (NSP14) (ExoN Products)
    Synonyms
    pp1ab antibody, ORF1a polyprotein;ORF1ab polyprotein antibody, ORF1ab antibody
    Target Type
    Viral Protein
    Background
    Coronavirus disease 2019 (COVID-19), formerly known as 2019-nCoV acute respiratory disease, is an infectious disease caused by SARS-CoV-2, a virus closely related to the SARS virus (1). The disease is the cause of the 2019-20 coronavirus outbreak (2). The structure of 2019-nCoV consists of the following: a spike protein (S), hemagglutinin-esterease dimer (HE), a membrane glycoprotein (M), an envelope protein (E) a nucleoclapid protein (N) and RNA. NSP14 (ExoN) is an enzyme possessing two different activities: an exoribonuclease activity acting on both ssRNA and dsRNA in a 3' to 5' direction and a N7-guanine methyltransferase activity (3,4,5). It acts as a proofreading exoribonuclease for RNA replication, thereby lowering The sensitivity of the virus to RNA mutagens(6,7,8).
    Gene ID
    43740578
    NCBI Accession
    YP_009725309
    UniProt
    P0DTC1
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