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IRAK1 antibody (AA 618-712)
IRAK1
Reactivity: Human, Mouse
WB, ELISA, IHC (p)
Host: Mouse
Monoclonal
8F1A7
unconjugated
Product Details anti-IRAK1 Antibody
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Target
See all IRAK1 Antibodies
IRAK1
(Interleukin-1 Receptor-Associated Kinase 1 (IRAK1))
Binding Specificity
All epitopes for IRAK1 antibodies
AA 618-712
Reactivity
All reactivities for IRAK1 antibodies
Human, Mouse
Host
All hosts for IRAK1 antibodies
Mouse
Clonality
All clonalities for IRAK1 antibodies
Monoclonal
Conjugate
All conjugates for IRAK1 antibodies
This IRAK1 antibody is un-conjugated
Application
All applications for IRAK1 antibodies
Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Purification
IRAK Monoclonal Antibody is Protein G purified.
Immunogen
Recombinant protein corresponding to amino acids 618 - 712 of human IRAK.
Clone
8F1A7
Isotype
IgG1
Top Product
Discover our top product IRAK1 Primary Antibody
Alternatives
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Application Details
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Application Notes
IRAK antibody can be used for Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL. Antibody validated: Western Blot in mouse samples and Immunohistochemistry in rat samples. All other applications and species not yet tested.
Restrictions
For Research Use only
Handling
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Format
Liquid
Concentration
1 mg/mL
Buffer
IRAK Monoclonal Antibody is supplied in PBS containing 0.02 % sodium azide.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
-20 °C
Storage Comment
IRAK monoclonal antibody can be stored at -20°C, stable for one year.
Target Details for IRAK1
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Target
IRAK1
(Interleukin-1 Receptor-Associated Kinase 1 (IRAK1))
Alternative Name
IRAK (IRAK1 Products )
Synonyms
IRAK1 antibody, IRAK antibody, pelle antibody, AA408924 antibody, IRAK-1 antibody, IRAK1-S antibody, Il1rak antibody, Plpk antibody, mPLK antibody, RGD1563841 antibody, interleukin 1 receptor associated kinase 1 antibody, interleukin-1 receptor-associated kinase 1 antibody, IRAK1 antibody, irak1 antibody, Irak1 antibody
Background
IRAK Monoclonal Antibody: Nuclear factor kappa B (NF-kappaB) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-κ,B mediates the expression of a great variety of genes in response to extracellular stimuli including IL-1, TNFalpha and LPS. A serine/threonine protein kinase associated with IL-1 receptor (IRAK) and its homologue mouse pelle-like protein kinase (mPLK) were identified recently. IRAK is associated with the IL-1 receptor subunits IL-1RI and IL-1RAcP after IL-1 binding and serves as a signaling molecule to mediate IL-1 response. IRAK mediates a signaling cascade leading to NF-κ,B activation by members in IL-1 family including IL-1 and a novel cytokine IL-18 (also termed IGIF).
Gene ID
3654
UniProt
P51617
Pathways
NF-kappaB Signaling , TLR Signaling , Neurotrophin Signaling Pathway , Activation of Innate immune Response , Cellular Response to Molecule of Bacterial Origin , Toll-Like Receptors Cascades
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