Caspase 4 antibody (N-Term)

Catalog No. ABIN6990327

This anti-Caspase 4 antibody is a Rabbit Polyclonal antibody detecting Caspase 4 in WB, ELISA and IHC (p). Suitable for Human, Mouse and Rat.

Quick Overview for Caspase 4 antibody (N-Term) (ABIN6990327)

Target: Caspase 4 (CASP4) (Caspase 4, Apoptosis-Related Cysteine Peptidase (CASP4))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Caspase 4 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-Caspase 4 Antibody

Binding Specificity: AA 80-130, N-Term

Purification: Caspase-13 Antibody is Ion exchange chromatography purified.

Immunogen: Caspase-13 antibody was raised against a 15 amino acid peptide near the amino terminus of bovine Caspase-13. The immunogen is located within amino acids 80 - 130 of Caspase-13.

Isotype: IgG

Application Details

Application Notes: Caspase-13 antibody can be used for detection of caspase-13 by Western blot at 1 μ,g/mL. A 43 kDa band should be detected. Antibody can also be used for immunohistochemistry starting at 10 μ,g/mL.

Antibody validated: Western Blot in human, mouse, and rat samples and Immunohistochemistry in mouse samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Caspase-13 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: Caspase-13 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for Caspase 4

Target: Caspase 4 (CASP4) (Caspase 4, Apoptosis-Related Cysteine Peptidase (CASP4))

Alternative Name: Caspase-13

Background: Caspase-13 Antibody: Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death is finally caused by members of the caspase family of proteases and caspase activated DNases. A novel member in the caspase family was recently identified and designated ERICE (for Evolutionarily Related Interleukin-1 beta Converting Enzyme) and caspase-13. Caspase-13 belongs to the ICE subfamily of caspases. Overexpression of caspase-13 induces apoptosis. Caspase-13 was activated by caspase-8, which is a key enzyme in death receptor induced apoptosis. Caspase-13 is expressed in a variety of human tissues and cell lines.

Molecular Weight: 43 kDa

Gene ID: 338039

UniProt: O75601

Pathways: Apoptosis, Caspase Cascade in Apoptosis, Positive Regulation of Endopeptidase Activity