BCMA antibody (C-Term)

Catalog No. ABIN6990362

The Rabbit Polyclonal anti-BCMA antibody is suitable to detect BCMA in samples from Human. It has been validated for ELISA, WB, IF and IHC (p).

Quick Overview for BCMA antibody (C-Term) (ABIN6990362)

Target: BCMA (TNFRSF17) (Tumor Necrosis Factor Receptor Superfamily, Member 17 (TNFRSF17))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BCMA antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-BCMA Antibody

Binding Specificity: C-Term

Purification: BCMA Antibody is affinity chromatography purified via peptide column.

Immunogen: BCMA antibody was raised against a 16 amino acid synthetic peptide mapping at the carboxy terminus of human BCMA. The immunogen is located within the last 50 amino acids of BCMA.

Isotype: IgG

Application Details

Application Notes: BCMA antibody can be used for detection of BCMA by Western blot at 5 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: BCMA Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: BCMA antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for BCMA

Target: BCMA (TNFRSF17) (Tumor Necrosis Factor Receptor Superfamily, Member 17 (TNFRSF17))

Alternative Name: BCMA

Background: BCMA Antibody: Members in the TNF superfamily regulate immune responses and induce apoptosis. Two novel members in the TNF family were recently identified and designated BAFF/BLyS/TALL-1/THANK/zTNF4 and April/TALL-2, respectively. BAFF was characterized as a B cell activator since it induced B cell proliferation and immunoglobulin secretion. April regulates immunological and non-immunological cell growth. Three receptors, BCMA (for B cell maturation protein), TACI, and BAFF-R, for BAFF were recently identified. BCMA, like TACI, binds BAFF and April. BAFF and its receptors induce B cell development and survival, activate NF-κ,B and c-jun N-terminal kinase, and are involved in B cell associated autoimmune diseases.

Molecular Weight: Predicted: 20 kDa

Observed: 27 kDa

Gene ID: 608

NCBI Accession: NP_001183

UniProt: Q02223