CARD10 antibody (N-Term)

Catalog No. ABIN6990438

The Rabbit Polyclonal anti-CARD10 antibody (ABIN6990438) specifically detects CARD10 in ELISA and IHC (p). The antibody is reactive with Human samples.

Quick Overview for CARD10 antibody (N-Term) (ABIN6990438)

Target: CARD10 (Caspase Recruitment Domain Family, Member 10 (CARD10))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CARD10 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-CARD10 Antibody

Binding Specificity: N-Term

Specificity: CARMA3 antibody is human specific. At least three isoforms of CARMA3 are known to exist, this antibody will only detect isoform 1. CARMA3 antibody is predicted not to cross-react with other CARMA proteins.

Purification: CARMA3 Antibody is affinity chromatography purified via peptide column.

Immunogen: CARMA3 antibody was raised against a 16 amino acid synthetic peptide near the amino terminus of human CARMA3. The immunogen is located within the first 50 amino acids of CARMA3.

Isotype: IgG

Application Details

Application Notes: CARMA3 antibody can be used for detection of CARMA3 by immunohistochemistry at 5 μ,g/mL.

Antibody validated: Immunohistochemistry in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: CARMA3 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: CARMA3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for CARD10

Target: CARD10 (Caspase Recruitment Domain Family, Member 10 (CARD10))

Alternative Name: CARMA3

Background: CARMA3 Antibody: CARMA proteins belong to the membrane-associated guanylate kinase-like (MAGUK) family of proteins that can function as molecular scaffolds that assist assembly of signal transduction molecules. CARMA1, CARMA2, and CARMA3 share high degrees of sequence and functional homology, but their tissue-specific distribution suggests that they serve distinct biological functions in different cell types. As with CARMA1, the CARD domain of CARMA3 has been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-κ,B activation. When expressed in cells, this protein binds to BCL10 and activates NF-κ,B Recent experiments have shown that CARMA3 is required for EGF-induced NF-κ,B activation and contributes to tumor growth in vivo, suggesting that CARMA3 may serve as a new therapeutic target for the treatment of EGFR-driven tumors.

Gene ID: 29775

NCBI Accession: NP_055365

UniProt: Q9BWT7

Pathways: S100 Proteins