BAX antibody (N-Term)

Catalog No. ABIN6990475

This Rabbit Polyclonal antibody specifically detects BAX in WB, ELISA, IF, IP and ICC. It exhibits reactivity toward Humanand has been mentioned in 1 publication.

Quick Overview for BAX antibody (N-Term) (ABIN6990475)

Target: BAX (BCL2-Associated X Protein (BAX))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BAX antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunoprecipitation (IP), Immunocytochemistry (ICC)

Product Details anti-BAX Antibody

Binding Specificity: N-Term

Purification: Bax Antibody is Ion exchange chromatography purified.

Immunogen: Bax antibody was raised against a peptide corresponding to 16 amino acids near the amino-terminus of human Bax. The immunogen is located within the first 50 amino acids of Bax.

Isotype: IgG

Application Details

Application Notes: Bax antibody can be used for detection of Bax by Western blot at 1 to 4 μ,g/mL. Antibody can also be used for immunocytochemistry starting at 2 μ,g/mL. For immunofluorescence start at 2 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Bax Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: Bax antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

References for anti-BAX antibody (ABIN6990475)

Tvrdá, Ďuračka, Benko, Kováčik, Lovíšek, Gálová, Žiarovská, Schwarzová, Kačániová: "Ejaculatory Abstinence Affects the Sperm Quality in Normozoospermic Men-How Does the Seminal Bacteriome Respond?" in: International journal of molecular sciences, Vol. 24, Issue 4, (2023) (PubMed).

Target Details for BAX

Target: BAX (BCL2-Associated X Protein (BAX))

Alternative Name: Bax

Background: Bax Antibody: Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. The Bcl-2 family of proteins is comprised of critical regulators of apoptosis that can be divided into two classes: those that inhibit apoptosis and those that promote cell death. Bax, a pro-apoptotic Bcl-2 family member, is a cytosolic protein that changes conformation and translocates to the mitochondria following apoptotic stimuli. It is thought to share significant functional homology with Bak, another pro-apoptotic Bcl-2 family member, as disruption of bax or bak has little effect on cell death, but mice lacking both genes display multiple developmental defects and cells lacking both show decreased apoptotic capability.

Gene ID: 581

UniProt: Q07812

Pathways: p53 Signaling, PI3K-Akt Signaling, Apoptosis, Caspase Cascade in Apoptosis, Positive Regulation of Endopeptidase Activity, Unfolded Protein Response