TMC8 antibody (N-Term)

Catalog No. ABIN6990929

Product Details anti-TMC8 Antibody

Target: TMC8 (Transmembrane Channel-Like 8 (TMC8))

Binding Specificity: AA 50-100, N-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TMC8 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Specificity: At least two isoforms of EVER2 are known to exist, this antibody will only recognize the larger isoform. EVER2 has no cross-reactivity to EVER1.

Purification: EVER2 Antibody is affinity chromatography purified via peptide column.

Immunogen: EVER2 antibody was raised against a 18 amino acid synthetic peptide from near the amino terminus of human EVER2. The immunogen is located within amino acids 50 - 100 of EVER2.

Isotype: IgG

Application Details

Application Notes: EVER2 antibody can be used for detection of EVER2 by Western blot at 1 - 2 μ,g/mL.

Antibody validated: Western Blot in rat samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: EVER2 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: EVER2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for TMC8

Target: TMC8 (Transmembrane Channel-Like 8 (TMC8))

Alternative Name: EVER2 (TMC8 Products)

Synonyms: EV2 antibody, EVER2 antibody, EVIN2 antibody, Ever2 antibody, mFLJ00400 antibody, transmembrane channel like 8 antibody, transmembrane channel-like 8 antibody, transmembrane channel-like gene family 8 antibody, TMC8 antibody, Tmc8 antibody

Background: EVER2 Antibody: Epidermodysplasia verruciformis (EV) is an autosomal recessive genodermatosis associated with a high risk of skin cancers resulting from a high susceptibility to infection by specific human papillomaviruses. Mutations in two homologous genes EVER1 and EVER2 cause the majority of EV cases. These two proteins form a complex and interact with the zinc transporter ZnT-1 in the endoplasmic reticulum. Cells lacking EVER2 accumulated higher levels of zinc in the nucleolus and nucleus compare to those cells with and intact EVER2 gene, indicating that one role of EVER2 is to regulate the intracellular distribution of zinc.

Gene ID: 147138

UniProt: Q8IU68