IL-17 antibody (N-Term)

Catalog No. ABIN6991007

Product Details anti-IL-17 Antibody

Target: IL-17 (IL17) (Interleukin 17 (IL17))

Binding Specificity: AA 40-90, N-Term

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IL-17 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Purification: IL-17 Antibody is affinity chromatography purified via peptide column.

Immunogen: IL-17 antibody was raised against a 16 amino acid synthetic peptide from near the amino terminus of human IL-17A. The immunogen is located within amino acids 40 - 90 of IL-17.

Isotype: IgG

Application Details

Application Notes: WB: 0.125-4 μ,g/mL.

Antibody validated: Western Blot in human and mouse samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: IL-17 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: IL-17 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for IL-17

Target: IL-17 (IL17) (Interleukin 17 (IL17))

Alternative Name: IL-17 (IL17 Products)

Synonyms: CTLA8 antibody, IL-17 antibody, IL-17A antibody, IL17 antibody, Ctla-8 antibody, Ctla8 antibody, Il17 antibody, ChIL-17 antibody, IL-17F antibody, IL17A antibody, CTLA-8 antibody, interleukin 17A antibody, IL17A antibody, Il17a antibody

Background: IL-17 Antibody: Interleukin 17 (IL-17) is a family of pro-inflammatory cytokines produced by activated T cells and is thought to have a major role in the initiation and perpetuation of rheumatoid arthritis. IL-17 regulates the activities of NF-κ,B and mitogen-activated protein kinases such as ERK and JNK. In addition, IL-17 stimulates the expression of IL-6 and cyclooxygenase-2 and enhances the production of nitric oxide. IL-17-producing T helper cells (TH-17 cells) have been the subject of much attention due to the importance of IL-17 in the pathogenesis of autoimmune inflammation. Because of its role in autoimmune diseases, it is thought that targeting the production and action of IL-17 would be beneficial therapeutically in these diseases.

Molecular Weight: Predicted: 17.5kD

Observed: 20 kD (Post-modification: 1 N-linked glycosylation) kDa

Gene ID: 3605

NCBI Accession: NP_002181

UniProt: Q16552