KPNA2 antibody (N-Term)

Catalog No. ABIN6991414

Product Details anti-KPNA2 Antibody

Target: KPNA2 (Karyopherin alpha 2 (RAG Cohort 1, Importin alpha 1) (KPNA2))

Binding Specificity: AA 40-90, N-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KPNA2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: KPNA2 Antibody is affinity chromatography purified via peptide column.

Immunogen: KPNA2 antibody was raised against a 15 amino acid synthetic peptide near the amino terminus of human KPNA2. The immunogen is located within amino acids 40 - 90 of KPNA2.

Isotype: IgG

Application Details

Application Notes: KPNA2 antibody can be used for detection of KPNA2 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human and rat samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: KPNA2 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: KPNA2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for KPNA2

Target: KPNA2 (Karyopherin alpha 2 (RAG Cohort 1, Importin alpha 1) (KPNA2))

Alternative Name: KPNA2 (KPNA2 Products)

Synonyms: IPOA1 antibody, QIP2 antibody, RCH1 antibody, SRP1alpha antibody, ima2 antibody, importin antibody, 2410044B12Rik antibody, PTAC58 antibody, Rch1 antibody, ipoa1 antibody, kpna2 antibody, qip2 antibody, rch1 antibody, srp1alpha antibody, hm:zeh0389 antibody, hm:zeh0389r antibody, zgc:113902 antibody, zgc:86945 antibody, karyopherin subunit alpha 2 antibody, importin subunit alpha-2 antibody, Importin subunit alpha-2 antibody, karyopherin (importin) alpha 2 antibody, karyopherin alpha-2 subunit like L homeolog antibody, karyopherin alpha 2 (RAG cohort 1, importin alpha 1) antibody, KPNA2 antibody, EDI_246290 antibody, EDI_335040 antibody, ima2 antibody, Kpna2 antibody, kpna2.L antibody, kpna2 antibody

Background: KPNA2 Antibody: Karyopherin, a cytosolic and heterodimeric protein complex consisting of alpha and beta subunits, is responsible for targeting proteins with nuclear localization signals to the nuclear pore complex by an energy requiring, Ran-dependent mechanism. The alpha subunit and imported substrate enter the nucleus and accumulate in the nucleoplasm, while the beta subunit accumulates at the NPC. KPNA2 is the alpha subunit 2 of karyopherin, which forms a complex with importin subunit beta-1 and functions as a cargo carrier that transports various complexes from cytoplasm into nucleus. It is ubiquitously expressed and contains an IBB/importin beta domain, ten Armadillo repeats that bind "cargo" and three intervening nuclear localization sequences (NLSs). It has recently been reported to play an important role in tumorigenesis and tumor progression.

Gene ID: 3838

NCBI Accession: NP_002257

UniProt: P52292

Pathways: M Phase, Protein targeting to Nucleus