PAPPA2 antibody (N-Term)

Catalog No. ABIN6991429

Product Details anti-PAPPA2 Antibody

Target: PAPPA2 (Pappalysin 2 (PAPPA2))

Binding Specificity: AA 450-500, N-Term

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PAPPA2 antibody is un-conjugated

Application: Western Blotting (WB), Immunocytochemistry (ICC), ELISA, Immunofluorescence (IF)

Purification: PLAC3 Antibody is affinity chromatography purified via peptide column.

Immunogen: PLAC3 antibody was raised against a 15 amino acid synthetic peptide near the amino terminus of human PLAC3. The immunogen is located within amino acids 450 - 500 of PLAC3.

Isotype: IgG

Application Details

Application Notes: PLAC3 antibody can be used for detection of PLAC3 by Western blot at 1 μ,g/mL. Antibody can also be used for immunocytochemistry starting at 10 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PLAC3 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: PLAC3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for PAPPA2

Target: PAPPA2 (Pappalysin 2 (PAPPA2))

Alternative Name: PLAC3 (PAPPA2 Products)

Synonyms: PAPP-A2 antibody, PLAC3 antibody, Pappe antibody, PAPP-E antibody, PAPPE antibody, si:dkey-39f8.1 antibody, pappalysin 2 antibody, Pappa2 antibody, PAPPA2 antibody, pappa2 antibody

Background: PLAC3 Antibody: PLAC3 (placenta-specific protein 3), also known as PAPP-A2, is a metalloproteinase that cleaves the insulin-like growth factor-binding protein (IGFBP)-5 in a IGF-independent fashion. It has been suggested that the cleavage of IGFBP-5 and to a lesser extent IGFBP-3 produced in the maternal decidua promotes feto-placental growth. Recent studies have shown elevated levels of PLAC3 in hypertensive disorders of pregnancy including preeclampsia and HELLP (hemolysis, elevated liver enzymes, and low platelets) syndrome.

Gene ID: 60676

NCBI Accession: NP_064714

UniProt: Q9BXP8