SLC39A3 antibody (AA 110-160)

Catalog No. ABIN6991453

Product Details anti-SLC39A3 Antibody

Target: SLC39A3 (Solute Carrier Family 39 (Zinc Transporter), Member 3 (SLC39A3))

Binding Specificity: AA 110-160

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SLC39A3 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: ZIP3 Antibody is affinity chromatography purified via peptide column.

Immunogen: ZIP3 antibody was raised against a 16 amino acid synthetic peptide near the center of human ZIP3. The immunogen is located within amino acids 110 - 160 of ZIP3.

Isotype: IgG

Application Details

Application Notes: ZIP3 antibody can be used for detection of ZIP3 by Western blot at 1 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL.

Antibody validated: Western Blot in mouse samples and Immunohistochemistry in mouse samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: ZIP3 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: ZIP3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for SLC39A3

Target: SLC39A3 (Solute Carrier Family 39 (Zinc Transporter), Member 3 (SLC39A3))

Alternative Name: ZIP3 (SLC39A3 Products)

Synonyms: AI845814 antibody, Zip3 antibody, ZIP3 antibody, wu:fc84e09 antibody, zgc:158334 antibody, solute carrier family 39 (zinc transporter), member 3 antibody, solute carrier family 39 member 3 antibody, Slc39a3 antibody, slc39a3 antibody, SLC39A3 antibody

Background: ZIP3 Antibody: The zinc transporter ZIP3, also known as SLC39A3, is a member of a family of divalent ion transporters. Zinc is an essential ion for cells and plays significant roles in the growth, development, and differentiation. Similar to knock-outs of ZIP1 and ZIP2, ZIP3-null mice have no phenotypic differences compared to wild-type mice. Only when ZIP1, ZIP2, and ZIP3 genes are all eliminated and these mutant mice are fed a zinc-deficient diet do abnormalities such as reduced embryonic-membrane bound alkaline phosphatase activity and abnormal development occur, indicating that the ZIP1-3 proteins play an important, noncompensatory role when zinc is deficient. More recent studies have shown that ZIP2 and ZIP3 are down regulated in human prostate adenocarcinomatous glands, and may be important in the retention of zinc in the cellular compartment.

Gene ID: 29985

NCBI Accession: NP_653165

UniProt: Q9BRY0

Pathways: NF-kappaB Signaling, Neurotrophin Signaling Pathway, Autophagy