SLC39A14 antibody (AA 230-280)

Catalog No. ABIN6991461

Product Details anti-SLC39A14 Antibody

Target: SLC39A14 (Solute Carrier Family 39 (Zinc Transporter), Member 14 (SLC39A14))

Binding Specificity: AA 230-280

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SLC39A14 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Specificity: At least three isoforms of ZIP14 are known to exist, this antibody will detect both isoforms. ZIP14 antibody is predicted to not cross-react with other ZIP family members.

Purification: ZIP14 Antibody is affinity chromatography purified via peptide column.

Immunogen: ZIP14 antibody was raised against a 16 amino acid synthetic peptide near the center of human ZIP14. The immunogen is located within amino acids 230 - 280 of ZIP14.

Isotype: IgG

Application Details

Application Notes: ZIP14 antibody can be used for detection of ZIP14 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: ZIP14 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: ZIP14 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for SLC39A14

Target: SLC39A14 (Solute Carrier Family 39 (Zinc Transporter), Member 14 (SLC39A14))

Alternative Name: ZIP14 (SLC39A14 Products)

Synonyms: LZT-Hs4 antibody, NET34 antibody, ZIP14 antibody, cig19 antibody, BC021530 antibody, G630015O18Rik antibody, Zip14 antibody, fad123 antibody, solute carrier family 39 member 14 antibody, solute carrier family 39 (zinc transporter), member 14 antibody, SLC39A14 antibody, Slc39a14 antibody

Background: ZIP14 Antibody: The zinc transporter ZIP14, also known as SLC39A14, is a member of a family of divalent ion transporters. Zinc is an essential ion for cells and plays significant roles in the growth, development, and differentiation. The zinc transporter family is divided into four subfamilies (I, II, LIV-1 and gufA). ZIP14 is a glycosylated multipass plasma membrane protein that belongs to the ZIP transporter subfamily LIV-1. ZIP14 has been shown to contribute to the hypozincemia of inflammation and infection and is regulated in the liver by IL-6. In addition to zinc, ZIP14 is also involved in the cellular uptake of non-transferrin-bound iron as well as iron bound to transferrin.

Molecular Weight: Predicted: 54 kDa

Observed: 52 kDa

Gene ID: 23516

NCBI Accession: NP_001128625

UniProt: Q15043

Pathways: Transition Metal Ion Homeostasis