ZMYM2 antibody (N-Term)

Catalog No. ABIN6991475

Product Details anti-ZMYM2 Antibody

Target: ZMYM2 (Zinc Finger, MYM-Type 2 (ZMYM2))

Binding Specificity: AA 120-170, N-Term

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ZMYM2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificity: At least two isoforms of ZMYM2 are known to exist, this antibody will detect only the longest isoform. ZMYM2 antibody is predicted to not cross-react with other ZMYM protein family members.

Purification: ZMYM2 Antibody is affinity chromatography purified via peptide column.

Immunogen: ZMYM2 antibody was raised against a 17 amino acid peptide near the amino terminus of human ZMYM2. The immunogen is located within amino acids 120 - 170 of ZMYM2.

Isotype: IgG

Application Details

Application Notes: ZMYM2 antibody can be used for detection of ZMYM2 by Western blot at 0. 125 - 0.25 μ,g/mL. Antibody can also be used for immunocytochemistry starting at 10 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in mouse samples, Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: ZMYM2 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: ZMYM2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for ZMYM2

Target: ZMYM2 (Zinc Finger, MYM-Type 2 (ZMYM2))

Alternative Name: ZMYM2 (ZMYM2 Products)

Synonyms: ZMYM2 antibody, ZNF198 antibody, fc07a10 antibody, wu:fc07a10 antibody, si:dkey-51d17.6 antibody, fim antibody, mym antibody, ramp antibody, scll antibody, zfp198 antibody, znf198 antibody, MGC83724 antibody, FIM antibody, MYM antibody, RAMP antibody, SCLL antibody, 5830413P05Rik antibody, Zfp198 antibody, Znf198 antibody, zinc finger MYM-type containing 2 antibody, zinc finger, MYM-type 2 antibody, zinc finger MYM-type containing 2 L homeolog antibody, ZMYM2 antibody, zmym2 antibody, zmym2.L antibody, Zmym2 antibody

Background: Zinc-finger proteins contain DNA-binding domains characterized by the unique role of zinc and have a wide variety of functions such as transcriptional activation or repression (1). The protein folding and the DNA binding ability are governed by the coordination of a zinc ion (1-3). As a member of the MYM (myeloproliferative and mental retardation) gene family, ZMYM2 has been shown to associate with and stabilize the LSD1-CoREST-HDAC1 (LCH) complex of chromatin through its MYM-type zinc fingers, thereby enhancing the transcriptional repression of several genes (4). Translocation of this gene with the fibroblast growth factor receptor-1 gene (FGFR1) results in a fusion gene, which may be a cause of stem cell leukemia lymphoma syndrome (SCLL) (5).

Gene ID: 7750

UniProt: Q9UBW7