TFEB antibody (C-Term)

Catalog No. ABIN6991678

Product Details anti-TFEB Antibody

Target: TFEB (Transcription Factor EB (TFEB))

Binding Specificity: AA 390-440, C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TFEB antibody is un-conjugated

Application: ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificity: TFEB antibody is human specific. At least three isoforms of TFEB are known to exist.

Purification: TFEB antibody is affinity chromatography purified via peptide column.

Immunogen: Rabbit polyclonal TFEB antibody was raised against a 16 amino acid peptide near the carboxy terminus of human TFEB. The immunogen is located within amino acids 390 - 440 of TFEB.

Isotype: IgG

Application Details

Application Notes: TFEB antibody can be used for detection of TFEB by immunohistochemistry at 2.5 μ,g/mL.

Antibody validated: Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: TFEB antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: TFEB antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Target Details for TFEB

Target: TFEB (Transcription Factor EB (TFEB))

Alternative Name: TFEB (TFEB Products)

Synonyms: TFEB antibody, tcfeb antibody, MGC145796 antibody, alphatfeb antibody, ALPHATFEB antibody, BHLHE35 antibody, TCFEB antibody, Tcfeb antibody, bHLHe35 antibody, transcription factor EB antibody, TFEB antibody, tfeb antibody, Tfeb antibody

Background: The Transcription factor EB (TFEB) is a member in the basic helix-loop-helix leucine zipper superfamily of transcription factors that is translocated in a subset of renal tumors (1,2). Recent studies have shown that lysosomal biogenesis is regulated by TFEB (3), which is in turn regulated by the mammalian target of rapamycin (mTOR) complex 1 (4). Other evidence suggests that TFEB coordinates the major steps of the autophagic pathway by driving the expression of autophagy and lysosomal genes (5).

Gene ID: 7942

NCBI Accession: NP_009093

UniProt: P19484