PTPRD antibody (N-Term)

Catalog No. ABIN6991696

This Rabbit Polyclonal antibody specifically detects PTPRD in WB and ELISA. It exhibits reactivity toward Human.

Quick Overview for PTPRD antibody (N-Term) (ABIN6991696)

Target: PTPRD (Protein tyrosine Phosphatase, Receptor Type, D (PTPRD))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PTPRD antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-PTPRD Antibody

Binding Specificity: N-Term

Specificity: PTPRD antibody is human specific. At least three alternatively spliced transcript variants encoding distinct isoforms have been observed. PTPRD cleavage products are often observed in vivo

Purification: PTPRD Antibody is affinity chromatography purified via peptide column.

Immunogen: PTPRD antibody was raised against an 18 amino acid synthetic peptide near the amino terminus of human PTPRD. The immunogen is located within the first 50 amino acids of PTPRD.

Isotype: IgG

Application Details

Application Notes: PTPRD antibody can be used for detection of PTPRD by Western blot at 1 - 2 μ,g/mL.

Antibody validated: Western Blot in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PTPRD Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: PTPRD antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for PTPRD

Target: PTPRD (Protein tyrosine Phosphatase, Receptor Type, D (PTPRD))

Alternative Name: PTPRD

Background: PTPRD Antibody: PTPRD (Protein tyrosine phosphatase receptor type D) is a member of the protein tyrosine phosphatase (PTP) family that plays diverse roles during development including cell growth, differentiation, mitotic cycle and oncogenic transformation. PTPRD contains an extracellular region, a single transmembrane segment and two tandem intracytoplasmic catalytic domains. The extracellular region of PTPRD is composed of three Ig-like and eight fibronectin type III-like domains (1,3). PTPRD interacts with PPFIA1-3 and is a tumor suppressor on chromosome 9p that is involved in the development of glioblastoma multiforme (GBMs) and multiple human cancers.

Molecular Weight: Predicted: 165, 210 kDa (130 kDa for cleavage product)

Observed: 130 kDa

Gene ID: 5789

NCBI Accession: NP_569075

UniProt: P23468

Pathways: Synaptic Membrane