CRB1 antibody (AA 780-830)

Catalog No. ABIN6991795

Product Details anti-CRB1 Antibody

Target: CRB1 (Crumbs Homolog 1 (CRB1))

Binding Specificity: AA 780-830

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CRB1 antibody is un-conjugated

Application: ELISA, Western Blotting (WB)

Specificity: Alternatively spliced transcript variants have been observed. CRB1 antibody i spredicted to not cross-react with CRB2.

Purification: CRB1 Antibody is affinity chromatography purified via peptide column.

Immunogen: Rabbit polyclonal CRB1 antibody was raised against an 18 amino acid peptide near the center of human CRB1. The immunogen is located within amino acids 780 - 830 of CRB1.

Isotype: IgG

Application Details

Application Notes: CRB1 antibody can be used for detection of CRB1 by Western blot at 1 - 2 μ,g/mL.

Antibody validated: Western Blot in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: CRB1 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: CRB1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Target Details for CRB1

Target: CRB1 (Crumbs Homolog 1 (CRB1))

Alternative Name: CRB1 (CRB1 Products)

Synonyms: CRB1 antibody, si:dkey-114d20.6 antibody, si:dkey-114d20.7 antibody, LCA8 antibody, RP12 antibody, 7530426H14Rik antibody, A930008G09Rik antibody, crumbs 1, cell polarity complex component antibody, crumbs family member 1, photoreceptor morphogenesis associated antibody, CRB1 antibody, crb1 antibody, Crb1 antibody

Background: CRB1 Antibody: CRB1 (Crumbs homolog 1) plays a role in photoreceptor morphogenesis in the retina. It may maintain cell polarization and adhesion. CRB1 is similar to the Drosophila crumbs protein and localizes to the inner segment of mammalian photoreceptors. The first identified human homolog, CRB1, is expressed in retina and some parts of the brain, leaving room for another homolog to function in epithelial tissues. Mutations in this gene are associated with a severe form of retinitis pigmentosa, RP12, and with Leber congenital amaurosis.

Molecular Weight: Predicted: 142 kDa

Gene ID: 23418

NCBI Accession: NP_001180569

UniProt: P82279

Pathways: Notch Signaling