PTRF antibody (C-Term)

Catalog No. ABIN6991834

Product Details anti-PTRF Antibody

Target: PTRF (Polymerase I and Transcript Release Factor (PTRF))

Binding Specificity: AA 270-320, C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PTRF antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificity: At least three isoforms of PTRF are known to exist, this antibody detects all three isoforms. It is predicted to not cross-react with other members of the cavin family.

Purification: PTRF Antibody is affinity chromatography purified via peptide column.

Immunogen: Rabbit polyclonal PTRF antibody was raised against a 19 amino acid peptide near the carboxy terminus of human PTRF. The immunogen is located within amino acids 270 - 320 of PTRF.

Isotype: IgG

Application Details

Application Notes: PTRF antibody can be used for detection of PTRF by Western blot at 0.5 - 1 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PTRF Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: PTRF antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Target Details for PTRF

Target: PTRF (Polymerase I and Transcript Release Factor (PTRF))

Alternative Name: PTRF (PTRF Products)

Synonyms: MGC53017 antibody, MGC89141 antibody, PTRF antibody, fd20g07 antibody, ptrf antibody, wu:fd20g07 antibody, zgc:162917 antibody, CAVIN antibody, CAVIN1 antibody, CGL4 antibody, cavin-1 antibody, 2310075E07Rik antibody, AW546441 antibody, Cav-p60 antibody, Cavin antibody, caveolae associated protein 1 L homeolog antibody, polymerase I and transcript release factor antibody, caveolae associated protein 1 antibody, caveolae associated protein 1b antibody, caveolae associated 1 antibody, cavin1.L antibody, PTRF antibody, cavin1 antibody, CAVIN1 antibody, cavin1b antibody, Cavin1 antibody

Background: PTRF Antibody: The polymerase I and transcript release factor (PTRF) enables the dissociation of paused ternary polymerase I transcription complexes from the 3' end of pre-rRNA transcripts, regulating rRNA transcription by promoting the dissociation of transcription complexes and the re-initiation of polymerase I on nascent rRNA transcripts. PTRF also localizes to caveolae at the plasma membrane and is thought to play a critical role in the formation of caveolae and the stabilization of caveolins, translocating from caveolae to the cytoplasm after insulin stimulation. PTRF is also thought to modify lipid metabolism and insulin-regulated gene expression. Mutations in this gene result in a disorder characterized by generalized lipodystrophy and muscular dystrophy.

Molecular Weight: 43 kDa

Gene ID: 284119

NCBI Accession: NP_036364

UniProt: Q6NZI2