GABARAPL2 antibody (C-Term)

Catalog No. ABIN6992033

Product Details anti-GABARAPL2 Antibody

Target: GABARAPL2 (GABA(A) Receptor-Associated Protein-Like 2 (GABARAPL2))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GABARAPL2 antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificity: GABARAPL2 antibody is human, mouse and rat reactive. Multiple isoforms of GABARAPL2 are known to exist.

Purification: GABARAPL2 antibody is affinity chromatography purified via peptide column.

Immunogen: GABARAPL2 antibody was raised against a 15 amino acid peptide near the carboxy terminus of human GABARAPL2. The immunogen is located within the last 50 amino acids of GABARAPL2.

Isotype: IgG

Application Details

Application Notes: GABARAPL2 antibody can be used for detection of GABARAPL2 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for Immunohistochemistry at 5 μ,g/mL. For Immunoflorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in mouse and rat samples and Immunofluorescence in mouse and rat samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: GABARAPL2 antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: GABARAPL2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Target Details for GABARAPL2

Target: GABARAPL2 (GABA(A) Receptor-Associated Protein-Like 2 (GABARAPL2))

Alternative Name: GABARAPL2 (GABARAPL2 Products)

Synonyms: GABARAPL2 antibody, atg8 antibody, gef2 antibody, gate16 antibody, gate-16 antibody, Gef2 antibody, ATG8 antibody, ATG8C antibody, GATE-16 antibody, GATE16 antibody, GEF-2 antibody, GEF2 antibody, zgc:92319 antibody, 0610012F20Rik antibody, 2900019O08Rik antibody, AI173605 antibody, GABA type A receptor associated protein like 2 antibody, GABA(A) receptor-associated protein like 2 antibody, GABA(A) receptor-associated protein like 2 L homeolog antibody, gamma-aminobutyric acid (GABA) A receptor-associated protein-like 2 antibody, GABARAPL2 antibody, gabarapl2 antibody, Gabarapl2 antibody, gabarapl2.L antibody

Background: Gamma-aminobutyric acid (GABA) is the main inhibitory transmitter by increasing a Cl-conductance that inhibits neuronal firing in the central nervous system (1). It has been shown to activate both ionotropic (GABAA) and metabotropic (GABAB) receptors as well as a third class of receptors called GABAC (2). GABARAPL2 (GABAA receptor-associated protein-like 2), also known as GATE16, was initially identified as a membrane transport modulator and is a mammalian ortholog to the autophagy protein ATG8 (3,4). It is thought that GABARAPL2 and other members of the ATG8 family act as scaffolds for assembly of the Unc-51 like kinase (ULK) complex in the formation of autophagosomes (5).

Molecular Weight: Predicted: 13 kDa

Observed: 13 kDa

Gene ID: 11345

NCBI Accession: NP_009216

UniProt: P60520

Pathways: Autophagy