XKR8 antibody (C-Term)

Catalog No. ABIN6992061

Product Details anti-XKR8 Antibody

Target: XKR8 (XK, Kell Blood Group Complex Subunit-Related Family, Member 8 (XKR8))

Binding Specificity: C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This XKR8 antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificity: XKR8 antibody is human reactive. At least two isoforms are known to exist, this antibody will detect both isoforms.

Purification: XKR8 antibody is affinity chromatography purified via peptide column.

Immunogen: XKR8 antibody was raised against a 15 amino acid peptide near the carboxy terminus of human XKR8. The immunogen is located within the last 50 amino acids of XKR8.

Isotype: IgG

Application Details

Application Notes: XKR8 antibody can be used for detection of XKR8 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: XKR8 antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: XKR8 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Target Details for XKR8

Target: XKR8 (XK, Kell Blood Group Complex Subunit-Related Family, Member 8 (XKR8))

Alternative Name: XKR8 (XKR8 Products)

Synonyms: 4931440N07Rik antibody, AI597014 antibody, Gm1031 antibody, XRG8 antibody, RP11-460I13.3 antibody, X-linked Kx blood group related 8 antibody, XK related 8 antibody, Xkr8 antibody, XKR8 antibody

Background: The XK Kell blood group complex subunit-related family member 8 (XKR8) is a member of a family of proteins that promote the phagocytosis of dying cells by altering the phospholipid distribution of the plasma membrane (1). XKR8 is thought to be a ""scramblase"", an enzyme that eliminates the asymmetry of phospholipid distribution in the plasma membrane. In apoptotic cells, XKR8 promotes the cell-surface exposure of phosphatidylserine (PtdSer) which serves as a signal for phagocytosis (1,2).

Molecular Weight: Predicted: 43 kDa

Observed: 47 kDa

Gene ID: 55113

NCBI Accession: NP_060523

UniProt: Q9H6D3