CTHRC1 antibody (N-Term)

Catalog No. ABIN6992108

Product Details anti-CTHRC1 Antibody

Target: CTHRC1 (Collagen Triple Helix Repeat Containing 1 (CTHRC1))

Binding Specificity: N-Term

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CTHRC1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Specificity: CTHRC1 antibody is human, mouse and rat reactive. At least two isoforms of CTHRC1 are known to exist, this antibody will detect only the larger isoform.

Purification: CTHRC1 antibody is affinity chromatography purified via peptide column.

Immunogen: CTHRC1 antibody was raised against a 19 amino acid peptide near the amino terminus of human CTHRC1. The immunogen is located within the first 50 amino acids of CTHRC1.

Isotype: IgG

Application Details

Application Notes: CTHRC1 antibody can be used for detection of CTHRC1 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in rat samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: CTHRC1 antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: CTHRC1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Target Details for CTHRC1

Target: CTHRC1 (Collagen Triple Helix Repeat Containing 1 (CTHRC1))

Alternative Name: CTHRC1 (CTHRC1 Products)

Synonyms: CTHRC1 antibody, cthrc1 antibody, zgc:101075 antibody, 1110014B07Rik antibody, collagen triple helix repeat containing 1 antibody, collagen triple helix repeat containing 1a antibody, CTHRC1 antibody, cthrc1 antibody, cthrc1a antibody, Cthrc1 antibody

Background: The Collagen triple helix repeat-containing protein (CTHRC1) is a glycosylated, secreted protein that is transiently expressed in the arterial wall in response to injury where it is thought to contribute to vascular remodeling by inhibiting collagen expression and deposition and promoting cell migration (1). CTHRC1 is highly expressed multiple human cancers, including pancreatic cancer where it plays a significant role in the progression and metastasis of the disease by regulating migration and adhesion of tumors cells (2). CTHRC1 overexpression can also be used as an independent prognostic marker in gastric cancer (3). Mutations at this locus have been associated with Barrett esophagus and esophageal adenocarcinoma (4).

Molecular Weight: Predicted: 27 kDa

Observed: 27 kDa

Gene ID: 115908

NCBI Accession: NP_612464

UniProt: Q96CG8

Pathways: Tube Formation