TIGIT antibody (Extracellular Domain) (Biotin)

Catalog No. ABIN6992251

This Mouse Monoclonal antibody specifically detects TIGIT in ELISA. It exhibits reactivity toward Human.

Quick Overview for TIGIT antibody (Extracellular Domain) (Biotin) (ABIN6992251)

Target: TIGIT (T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This TIGIT antibody is conjugated to Biotin

Application: ELISA

Clone: 10B1

Product Details anti-TIGIT Antibody (Biotin)

Binding Specificity: Extracellular Domain

Purification: TIGIT Antibody is supplied as protein A purified IgG1.

Immunogen: TIGIT antibody was raised against the extracellular domain of human TIGIT

Isotype: IgG1

Application Details

Application Notes: TIGIT antibody can be used for as detection antibody in Sandwich Elisa at 1 μ,g/mL.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: TIGIT Antibody is supplied in PBS containing 1 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: TIGIT antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for TIGIT

Target: TIGIT (T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT))

Alternative Name: TIGIT

Background: TIGIT Antibody: The T cell immunoreceptor with Ig and ITIM domains (TIGIT) is a member of the PVR (poliovirus receptor) family of immunoglobin proteins. It is expressed on several classes of T cells including follicular B helper T cells (TFH). TIGIT has been shown to bind PVR with high affinity, this binding is thought to assist interactions between TFH and dendritic cells to regulate T cell dependent B cell responses (1). Similar to other immune checkpoint proteins such as PD-1, TIGIT is upregulated on exhausted T cells in chronic viral infections and cancer. Blockade of both TIGIT and PD-1 pathways leads to tumor rejection in mice suggesting that it may be of therapeutic use against cancer (2).

Gene ID: 201633

NCBI Accession: NP_776160

UniProt: Q495A1

Pathways: Cancer Immune Checkpoints