MAPT antibody (AA 34-368)

Catalog No. ABIN7434482

Product Details anti-MAPT Antibody

Key Features:

• High quality MAPT Primary Antibody for the detection of MAPT.
• Reliable product with high standard validation data

Target: MAPT (Microtubule-Associated Protein tau (MAPT))

Binding Specificity: AA 34-368

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MAPT antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunocytochemistry (ICC)

Purpose: Polyclonal Antibody to Tau Protein (MAPT)

Specificity: The antibody is a rabbit polyclonal antibody raised against MAPT. It has been selected for its ability to recognize MAPT in immunohistochemical staining and western blotting.

Cross-Reactivity: Mouse

Purification: Antigen-specific affinity chromatography followed by Protein A affinity chromatography

Immunogen: Recombinant Tau Protein (MAPT) corresdonding to Ala34~Ser368 with N-terminal His Tag

Isotype: IgG

Product Specific Information:

What can the MAPT Antibody ABIN7434482 be used for?: This polyclonal MAPT Antibody detects MAPT. The MAPT Antibody has been validated for various applications and can be used for the detection of MAPT and derivatives by Western Blotting, Immunohistochemistry, Immunoprecipitation, Immunocytochemistry.

What validation data is available for this MAPT Antibody?: The primary antibody has currently 5 product images that show its performance in a variety of applications. The product is currently available in 1 mL, 20 μL, 100 μL, 200 μL quantities. MAPT Antibody for the detection of MAPT and derivatives.

What is the function of MAPT?: This gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy. [provided by RefSeq, Jul 2008].

Application Details

Application Notes: Western blotting: 0.5-2 μg/mL,Immunohistochemistry: 5-20 μg/mL,Immunocytochemistry: 5-20 μg/mL,Optimal working dilutions must be determined by end user.

Comment:

The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, pH 7.4, containing 0.02 % Sodium azide, 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for frequent use. Stored at -20°C in a manual defrost freezer for two year without detectable loss of activity. Avoid repeated freeze-thaw cycles.

Expiry Date: 24 months

Target Details for MAPT

Target: MAPT (Microtubule-Associated Protein tau (MAPT))

Alternative Name: MAPT (MAPT Products)

Background: DDPAC, FTDP-17, MAPTL, MSTD, MTBT1, MTBT2, PPND, Neurofibrillary tangle protein, Microtubule Associated Protein Tau, Paired helical filament-tau, G Protein Beta1/Gamma2 Subunit-Interacting Factor 1

UniProt: P19332

Pathways: MAPK Signaling, Microtubule Dynamics, M Phase, Regulation of Cell Size