STIL antibody

Catalog No. ABIN7233972

Product Details anti-STIL Antibody

Target: STIL (SCL/TAL1 Interrupting Locus (STIL))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This STIL antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Characteristics: Polyclonal Antibody

Purification: Affinity purification

Immunogen: Recombinant Human SCL-interrupting locus protien

Isotype: IgG

Application Details

Application Notes: IHC 1:50-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 2 mg/mL

Buffer: PBS with 0.05 % Proclin300 and 50 % glycerol, pH 7.4.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for STIL

Target: STIL (SCL/TAL1 Interrupting Locus (STIL))

Alternative Name: STIL (STIL Products)

Synonyms: Sil antibody, MCPH7 antibody, SIL antibody, chunp6907 antibody, sill antibody, zgc:110502 antibody, STIL, centriolar assembly protein antibody, Scl/Tal1 interrupting locus antibody, STIL, centriolar assembly protein L homeolog antibody, scl/tal1 interrupting locus antibody, Stil antibody, STIL antibody, stil.L antibody, stil antibody

Background: This gene encodes a cytoplasmic protein implicated in regulation of the mitotic spindle checkpoint, a regulatory pathway that monitors chromosome segregation during cell division to ensure the proper distribution of chromosomes to daughter cells. The protein is phosphorylated in mitosis and in response to activation of the spindle checkpoint, and disappears when cells transition to G1 phase. It interacts with a mitotic regulator, and its expression is required to efficiently activate the spindle checkpoint. It is proposed to regulate Cdc2 kinase activity during spindle checkpoint arrest. Chromosomal deletions that fuse this gene and the adjacent locus commonly occur in T cell leukemias, and are thought to arise through illegitimate V-(D)-J recombination events. Multiple transcript variants encoding different isoforms have been found for this gene.

UniProt: Q15468

Pathways: Tube Formation