IRAK1BP1 antibody

Catalog No. ABIN7235229

Product Details anti-IRAK1BP1 Antibody

Target: IRAK1BP1 (Interleukin-1 Receptor-Associated Kinase 1 Binding Protein 1 (IRAK1BP1))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IRAK1BP1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Characteristics: Polyclonal Antibody

Purification: Affinity purification

Immunogen: Recombinant protein of human IRAK1BP1

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000, IHC 1:50-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.4 mg/mL

Buffer: PBS with 0.05 % sodium azide and 50 % glycerol, PH7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for IRAK1BP1

Target: IRAK1BP1 (Interleukin-1 Receptor-Associated Kinase 1 Binding Protein 1 (IRAK1BP1))

Alternative Name: IRAK1BP1 (IRAK1BP1 Products)

Synonyms: AIP70 antibody, SIMPL antibody, 4921528N06Rik antibody, AI851240 antibody, Aabp3 antibody, Aip70 antibody, Simpl antibody, zgc:112481 antibody, interleukin 1 receptor associated kinase 1 binding protein 1 antibody, interleukin-1 receptor-associated kinase 1 binding protein 1 antibody, IRAK1BP1 antibody, Irak1bp1 antibody, irak1bp1 antibody

Background: SIMPL, also known as IRAK1BP1 (interleukin-1 receptor-associated kinase 1-binding protein 1), is a 260 amino acid protein belonging to the IRAK1BP1 family. In addition to containing an intrinsically disordered region which associates with HSPA1 and HSPA8, SIMPL also interacts directly with IRAK1 and promotes RELA transcriptional activity. SIMPL is a major component of the IRAK1-dependent TNFRSF1A signaling pathway in which TNF-alpha induces NF-kappa-B gene transcription, leading to an inhibition of proinflammatory cytokines. Inactivation of SIMPL inhibits tumor necrosis factor receptor type I-induced NF-kappaB activity. Localizing to the nucleus and cytoplasm, SIMPL requires the phosphorylation of Ser-56 and/or Ser-62 to be fully active.

Molecular Weight: 29 kDa

UniProt: Q5VVH5