9230105K17Rik antibody, Bpifd1 antibody, BPIFD1 antibody, rBPI antibody, bpi antibody, bpi.L antibody, lbp antibody, bactericidal/permeability-increasing protein antibody, bactericidal permeablility increasing protein antibody, bactericidal/permeability-increasing protein S homeolog antibody, BPI antibody, Bpi antibody, bpi.S antibody
Background
This gene encodes a lipopolysaccharide binding protein. It is associated with human neutrophil granules and has bactericidal activity on gram-negative organisms. The cytotoxic action of BPI is limited to many species of Gram-negative bacteria, this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. Has antibacterial activity against the Gram-nagative bacterium P.aeruginosa, this activity is inhibited by LPS from P.aeruginosa.