EID1 antibody

Catalog No. ABIN7241222

Product Details anti-EID1 Antibody

Target: EID1 (EP300 Interacting Inhibitor of Differentiation 1 (EID1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EID1 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Characteristics: Polyclonal Antibody

Purification: Affinity purification

Immunogen: Recombinant protein of human EID1

Isotype: IgG

Application Details

Application Notes: IHC 1:50-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.6 mg/mL

Buffer: PBS with 0.05 % sodium azide and 50 % glycerol, PH7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for EID1

Target: EID1 (EP300 Interacting Inhibitor of Differentiation 1 (EID1))

Alternative Name: EID1 (EID1 Products)

Synonyms: C15orf3 antibody, CRI1 antibody, EID-1 antibody, IRO45620 antibody, PTD014 antibody, RBP21 antibody, 2610002K20Rik antibody, Cri1 antibody, ORF12 antibody, PNAS-22 antibody, RGD1562702 antibody, EP300 interacting inhibitor of differentiation 1 antibody, EID1 antibody, Eid1 antibody

Background: E1A-like inhibitor of differentiation-1 (EID-1), an acetyltransferase enzyme, binds both the retinoblastoma protein (Rb), a regulator of cell cycle and tissue specific transcription, and the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. EID-1 inhibits cellular differentiation by blocking the histone acetyltransferase activity of p300. EID-1 also acetylates both histones and non-histone proteins such as NCOA3 co-activator. By acetylating histones, EID-1 gives a specific tag for transcriptional activation. In addition to binding Rb and p300, EID-1 also binds to phosphorylated CREB protein, mediating cAMP gene regulation. EID-1 augments the activity of phosphorylated CREB and activates transcription of cAMP responsive genes as a co-activator.

NCBI Accession: NP_055150

UniProt: Q9Y6B2