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HLA-DOB antibody

HLA-DOB Reactivity: Human WB, ELISA, IHC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN7245230
  • Target See all HLA-DOB Antibodies
    HLA-DOB (Major Histocompatibility Complex, Class II, DO beta (HLA-DOB))
    Reactivity
    • 24
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    Human
    Host
    • 18
    • 6
    Rabbit
    Clonality
    • 21
    • 3
    Polyclonal
    Conjugate
    • 15
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This HLA-DOB antibody is un-conjugated
    Application
    • 17
    • 8
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
    Characteristics
    Polyclonal Antibody
    Purification
    Antigen affinity purification
    Immunogen
    Synthetic peptide of human HLA-DOB
    Isotype
    IgG
  • Application Notes
    WB 1:500-1:2000, IHC 1:30-1:150, ELISA 1:5000-1:10000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1.2 mg/mL
    Buffer
    PBS with 0.05 % Sodium azide and 40 % Glycerol, pH 7.4
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Avoid freeze / thaw cycles.
  • Target
    HLA-DOB (Major Histocompatibility Complex, Class II, DO beta (HLA-DOB))
    Alternative Name
    HLA-DOB (HLA-DOB Products)
    Synonyms
    DOB antibody, major histocompatibility complex, class II, DO beta antibody, HLA-DOB antibody, PATR-DOB antibody
    Background
    HLA-DOB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DOA) and a beta chain (DOB), both anchored in the membrane. It is located in intracellular vesicles. DO suppresses peptide loading of MHC class II molecules by inhibiting HLA-DM. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. HLA-DOB (Major Histocompatibility Complex, Class II, DO Beta) is a Protein Coding gene. Among its related pathways are ICos-ICosL Pathway in T-Helper Cell and CTLA4 Signaling. GO annotations related to this gene include MHC class II protein complex binding and MHC class II receptor activity. An important paralog of this gene is HLA-DRB1.
    Molecular Weight

    Observed_MW: Refer to figures

    Calculated_MW: 31 kDa

    UniProt
    P13765
    Pathways
    Cancer Immune Checkpoints
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