C9ORF116 antibody

Catalog No. ABIN7246424

Product Details anti-C9ORF116 Antibody

Target: C9ORF116 (Chromosome 9 Open Reading Frame 116 (C9ORF116))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This C9ORF116 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Characteristics: Polyclonal Antibody

Purification: Antigen affinity purification

Immunogen: Fusion protein of human C9orf116

Isotype: IgG

Application Details

Application Notes: IHC 1:50-1:300, ELISA 1:5000-1:10000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.96 mg/mL

Buffer: PBS with 0.05 % Sodium azide and 40 % Glycerol, pH 7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for C9ORF116

Target: C9ORF116 (Chromosome 9 Open Reading Frame 116 (C9ORF116))

Alternative Name: C9orf116 (C9ORF116 Products)

Synonyms: PIERCE1 antibody, RbEST47 antibody, Rbest47 antibody, chromosome 9 open reading frame 116 antibody, RIKEN cDNA 1700007K13 gene antibody, chromosome ssa24 open reading frame, human C9orf116 antibody, chromosome 11 open reading frame, human C9orf116 antibody, C9orf116 antibody, 1700007K13Rik antibody, cssa24h9orf116 antibody, C11H9orf116 antibody

Background: C9orf116, also known as PIERCE1. PIERCE1 is an important p53 target gene contributing to normal DNA damage response and may play crucial roles in maintaining genomic integrity against genotoxic stresses, including UVC irradiation. PIERCE1 exists as two alternatively spliced isoforms and is predominantly expressed in human small cell lung cancer. PIERCE1 knockdown induces down-regulation of proapoptotic genes including Ei24, Apaf1 and PTEN, suggesting that PIERCE1 is a proapoptotic gene. It is helpful for in-depth understanding of p53 pathways and the design of new cancer therapies.

UniProt: Q5BN46