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CHEK2 antibody (pThr68)

Name: CHEK2 antibody (pThr68)
Brand: antibodies-online
SKU: ABIN7250719
Price: 538.8 USD
Availability: InStock

CHEK2 Reactivity: Human, Mouse, Rat WB, ELISA, IF, IHC (p) Host: Rabbit Polyclonal unconjugated

Western Blot analysis of Hela cells using Phospho-CHEK2 (Thr68) Polyclonal Antibody at dilution of 1:500 (CHEK2 antibody (pThr68))

Immunohistochemistry of paraffin-embedded Human uterus tissue using Phospho-CHEK2 (Thr68) Polyclonal Antibody at dilution of 1:200 (CHEK2 antibody (pThr68))

IHC (p)

Immunofluorescence analysis of Rat lung tissue using Phospho-CHEK2 (Thr68) Polyclonal Antibody at dilution of 1:200 (CHEK2 antibody (pThr68))

3 images

Catalog No. ABIN7250719

Datasheet as PDF

Target See all CHEK2 Antibodies

CHEK2 (Checkpoint Kinase 2 (CHEK2))
Binding Specificity
26

24

19

16

16

15

15

15

9

8

8

8

6

4

3

3

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
pThr68
Reactivity
235

87

73

16

13

7

6

5

2

2

2

1
Human, Mouse, Rat
Host
213

23

1
Rabbit
Compatible Secondaries
Clonality
207

30
Polyclonal
Conjugate
108

11

9

9

7

7

7

7

7

7

7

7

7

7

7

3

3

3

3

3

3

2

2

1
This CHEK2 antibody is un-conjugated
Application
199

79

78

68

39

35

30

29

24

18

17

5

1

1

1

1

1
Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Characteristics

Phosphorylated antibody

Purification

Affinity purification

Immunogen

Synthesized peptide derived from human Chk2 around the phosphorylation site of Thr68

Isotype

IgG

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Application Notes

WB 1:500-1:2000, IHC 1:100-1:300, IF 1:50-1:200, ELISA 1:10000-1:20000

Restrictions

For Research Use only
Format

Liquid

Concentration

1 mg/mL

Buffer

PBS with 0.02 % sodium azide, 0.5 % BSA and 50 % glycerol, pH 7.4

Preservative

Sodium azide

Precaution of Use

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage

-20 °C

Storage Comment

Store at -20°C. Avoid freeze / thaw cycles.
Target

CHEK2 (Checkpoint Kinase 2 (CHEK2))

Alternative Name

CHEK2 (CHEK2 Products)

Background

Regulates cell cycle checkpoints and apoptosis in response to DNA damage, particularly to DNA double-strand breaks. Inhibits CDC25C phosphatase by phosphorylation on 'Ser-216', preventing the entry into mitosis. May also play a role in meiosis. Regulates the TP53 tumor suppressor through phosphorylation at 'Thr-18' and 'Ser-20'.

Molecular Weight

Observed_MW: 61 kDa
Calculated_MW: 61 kDa

UniProt

O96017

Pathways

p53 Signaling, Apoptosis, Cell Division Cycle